| 肠淋巴再灌注对SMAO休克大鼠多器官ICAM-1、RAGE的作用 |
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| 引用本文： | 刘争杰,赵自刚,赵永泉,牛春雨,张玉平,司永华,张立民.肠淋巴再灌注对SMAO休克大鼠多器官ICAM-1、RAGE的作用[J].微循环学杂志,2011,21(3):1-3,11,88,90. |
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| 作者姓名： | 刘争杰 赵自刚 赵永泉 牛春雨 张玉平 司永华 张立民 |
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| 作者单位： | 河北北方学院微循环研究所,基础医学院病理生理学教研室,张家口,075000 |
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| 基金项目： | 国家自然科学基金资助项目，河北省科技支撑计划，张家口市科技攻关计划 |
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| 摘 要： | 目的:观察肠淋巴再灌注(MLR)对肠系膜上动脉闭塞性(SMAO)休克大鼠肺、心肌、肾、肝组织细胞间黏附分子-1(ICAM-1)、晚期糖基化终末产物受体(RAGE)含量的影响,探讨MLR加剧SMAO休克大鼠器官损伤的作用机制。方法:Wistar大鼠24只,随机均分为假手术组(Sham组)、MLR组、SMAO组和SMAO+MLR组,后三组大鼠分别夹闭肠系膜淋巴管和/或肠系膜动脉1h、再灌注2h。Sham组不夹闭。各组于相应时间点留取固定位置的肺、心肌、肾、肝组织,制备组织匀浆;应用酶联免疫方法检测各组织匀浆ICAM-1、RAGE含量。结果:Sham组和MLR组各指标无统计学差异;SMAO组和SMAO+MLR组肺、肾、心肌、肝组织ICAM-1、RAGE的含量均显著高于MLR组和Sham组(P均<0.01);SMAO+MLR组肺、肾、心肌、肝组织ICAM-1与RAGE含量显著高于SMAO组(P均<0.01)。结论:MLR加剧SMAO休克大鼠多器官损伤的作用机制与各器官组织ICAM-1、RAGE水平升高有关。
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| 关 键 词： | 肠淋巴再灌注 肠系膜上动脉闭塞性休克 多器官损伤 细胞间黏附分子-1 晚期糖基化终末产物受体 |
Role of Mesenteric Lymph Reperfusion on ICAM-1,RAGE of Multiple Organs in SMAO Shock Rats |
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| Liu Zhengjie,Zhao Zigang,Zhao Yongquan,et al/Institution of microcirculation.Role of Mesenteric Lymph Reperfusion on ICAM-1,RAGE of Multiple Organs in SMAO Shock Rats[J].Chinese Journal of Microcirculation,2011,21(3):1-3,11,88,90. |
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| Authors: | Liu Zhengjie Zhao Zigang Zhao Yongquan /Institution of microcirculation |
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| Institution: | Liu Zhengjie,Zhao Zigang,Zhao Yongquan,et al/Institution of microcirculation,Department of Pathophysiololgy of Basic Medical College,Hebei North University,Zhangjiakou 075000 |
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| Abstract: | Objective: To observe the effects of mesenteric lymph reperfusion(MLR) on the contents of intercellular adhesion molecule-1(ICAM-1) and receptor of advanced glycation end-products(RAGE) of lung,myocardium,kidney,liver in superior mesenteric artery occlusion(SMAO) shock rats,and investigate the mechanism of MLR aggravating organ injury in SMAO shock.Method: Twenty four Wistar rats were radomly divided into sham group,MLR group,SMAO group,SMAO+MLR group,after performing 1h occlusion of mesenteric lymphatic du... |
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| Keywords: | Mmesenteric lymph reperfusion(MLR) Superior mesenteric artery occlusion(SMAO) shock Multiple organ injury Intercellular adhesion molecule-1(ICAM-1) Receptor of advanced glycation end-products(RAGE) |
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