原发性高血压患者血浆同型半胱氨酸水平与脉搏波传导速度的相关性

目的通过分析原发性高血压患者血浆同型半胱氨酸(Hcy)水平与臂踝脉搏波传导速度(BaPWV)的相关性,探讨原发性高血压患者血浆Hcy水平与动脉僵硬度的关系。方法高血压病患者共146例,根据Hcy的四分位间距水平分成四组,同时根据BaPWV≥1400 cm/s为异常界值,分成BaPWV正常组和异常组。测定空腹血糖、血脂及Hcy,测定双侧BaPWV。结果 Hcy与年龄、吸烟史、收缩压(SBP)、脉压(PP)、脉压指数(PPI)及BaP-WV呈正相关(r分别为0.278、0.272、0.608、0.575、0.460及0.351,P<0.05),BaPWV与Hcy、SBP、PP及PPI呈正相关(r分别为0.351、0.322、0.322及0.253,P<0.01)。以BaPWV为因变量,进行Logistic回归方程分析,结果显示PP和Hcy是高血压病患者BaPWV升高的独立危险因素。结论 Hcy水平升高与高血压病患者动脉僵硬度的发生发展密切相关。

Correlation Analysis of Homocysteine and Pulse Wave Velocity in Essential Hypertensive Patients

Aim To investigate the association of plasma homocysteine(Hcy) with arterial stiffness,measured as brachial-ankle pulse wave velocity(BaPWV) in essential hypertensive patients.Methods 146 essential hypertensive patients were enrolled in the study.All the patients accepted physical examination,laboratorial checks,and coronary risk factors were recorded.They were classified into four groups according to interquartile interval of homocysteine.And they were also classified into two groups according to BaPWV.The differences among these groups were analyzed.Results The linear correlation analysis showed that Hcy was more positively correlated with age,smoking,systolic blood pressure(SBP),pulse pressure(PP),pulse pressure index(PPI) and BaPWV(r=0.278,0.272,0.608,0.575,0.460 and 0.351,P<0.05).BaPWV was more positively correlated with Hcy,SBP,PP and PPI(r=0.351,0.322,0.322 and 0.253,P<0.01).Multiple logistic regression analysis showed that PP and Hcy were both independent risk factors for BaPWV.ConclusionThis study showed a positive correlation between high levels of plasma Hcy and arterial stiffness measured as BaPWV in essential hypertensive patients.