肺通口服液对大鼠肺纤维化模型的治疗作用

①目的　观察肺通口服液对大鼠肺纤维化的治疗作用。②方法　观察不同浓度肺通口服液治疗后大鼠肺纤维化模型肺组织的超氧化物歧化酶 (SOD)的活性、羟脯氨酸 (HP)含量、丙二醛 (MDA)含量及其超微结构的变化等 ,并与对照组进行比较。③结果　大剂量组 (15 g/kg体质量 )第 14、2 8天时的SOD活性、HP含量、MDA含量、炎性细胞的个数、肺泡隔平均宽度及肺通气量 (CO2 、O2 )等指标与模型组比较 ,差异均有显著性 (F =3.0 3～188.0 8,q =3.34～ 37.0 0 ,P <0 .0 5、0 .0 1、0 .0 0 1)。肺通口服液组肺组织的超微结构也较对照组有明显改善。④结论　肺通口服液对大鼠肺纤维化模型具有治疗作用。

THE THERAPEUTIC EFFECTS OF FEI-TONG-KOU-FU-YE ON BLEOMYCIN INDUCED PULMONARY FIBROSIS IN RATS

Objective To study the possible therapeutic effects of Fei Tong Kou Fu Ye(Fei Tong oral drug solution) on bleomycin induced pulmonary fibrosis in rats. Methods The pulmonary fibrosis model was established by intratracheal administration of bleomycin. The activity of serum superoxide dismutase (SOD), the amount of malondialdehyde (MDA), hydroxyproline (HP) in lung homogenate, as well as the ultrastructure, changes were measured and compared with that of the control group. Results In high dose group(15 g/kg body weight), the differences were significant, on the 14th and 28th day, compared with model group, in terms of SOD, HP, MDA, the number of inflammatory cells and the mean width of alveolar septa ( F=3.03-188.08, q=3.34-37.00, P <0.05, 0.01, 0.001). The ultrastructure of the lung showed significant improvement after taking the solution. Conclusion Fei Tong Kou Fu Ye may have therapeutic effects on bleomycin induced pulmonary fibrosis in rats.