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| 含甘草总黄酮效应组分微丸的制备及性质考察 | |
| 引用本文： | 陈丽华,冯怡,徐德生,李俊松,张梁,汪益涵.含甘草总黄酮效应组分微丸的制备及性质考察[J].中药材,2008,31(3):434-438. |
| 作者姓名： | 陈丽华 冯怡 徐德生 李俊松 张梁 汪益涵 |
| 作者单位： | 1. 上海中医药大学,上海,201203;江西中医学院,江西南昌,330004 2. 上海中医药大学,上海,201203 3. 南京中医药大学,江苏南京,210029 |
| 基金项目： | 上海市重点学科建设项目 , 上海市科委科技计划 |
| 摘 要： | 目的应用挤出滚圆法制备含甘草总黄酮效应组分微丸,采用Eudragit RS 100为包衣材料,制备含甘草总黄酮效应组分缓释微丸.方法采用Mini Glatt流化床底喷包衣法制备包衣微丸,对其包衣工艺及处方进行单因素考察,评价微丸的粉体学性质和体外释放行为.结果当聚合物包衣增重6%,增塑剂用量为10%时,药物具有明显的缓释作用,体外释放曲线符合Peppas和Higuchi方程.结论制备的含甘草总黄酮效应组分微丸具备较理想的缓释效果. |
| 关 键 词： | 含甘草总黄酮效应组分 Eudragit RS 100 微丸 释放度 甘草总黄酮 效应 组分 包衣微丸 性质考察 Properties Pellets Components Effective Flavones Total Glycyrrhiza Preparation 缓释效果 方程 Higuchi 释放曲线 缓释作用 药物 用量 |
| 文章编号： | 1001-4454(2008)03-0434-05 |
| 修稿时间： | 2007年7月23日 |
Study on Preparation of Glycyrrhiza Total Flavones Effective Components Sustained-release Pellets and Its Properties |
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| CHEN Li-hua,FENG Yi,XU De-sheng,LI Jun-song,ZHANG Liang,WANG Yi-han.Study on Preparation of Glycyrrhiza Total Flavones Effective Components Sustained-release Pellets and Its Properties[J].Jorunal of Chinese Medicinal Materials,2008,31(3):434-438. | |
| Authors: | CHEN Li-hua FENG Yi XU De-sheng LI Jun-song ZHANG Liang WANG Yi-han |
| Institution: | Shanghai University of TCM, Shanghai 201203, China. chlly98@163.com |
| Abstract: | OBJECTIVE: To prepare the glycyrrhiza total flavones effective components pellets by extrusion-spheronization, and to optimize the formulation of glycyrrhiza total flavones effective components sustained release pellets coated with mixed Eudragit RS 100. METHODS: The sustained-release pellets of glycyrrhiza total flavones were prepared by Glatt fluid bed technique. The factors influencing the drug release behaviors and their properties were evaluated. RESULTS: The optimal drug sustained-release was shown at the loading weight of copolymers of 6% and the plasticizer concentration of 10%. And the curves of cumulative drug release were fit for Peppas and Higuchi equation. CONCLUSION: The pellets show obviously sustained-release effect. |
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