P波离散度与扩张型心肌病的关系

目的：研究P波离散度（PWD）在扩张型心肌病中的表现。方法：研究对象分为两组，研究组为53例扩张型心肌病患者，对照组为53例健康查体者。测量心电图P波最大时限（Pmax）及P波最小时限（Pmin），PWD=Pmax—Pmin。用超声心动图测量左心房内径（LAD）、舒张末期左心室内径（LVEDD）、收缩末期左心室内径（LVESD）及左心室射血分数（LVEF）。结果：扩张性型心肌病患者的Pmax及PWD均明显延长，与对照组相比，差异显著（P〈0．001），而Pmin两组间无显著差异（P〉0．05）。Pmax及PWD与LAD均呈正相关（r=0．533，P〈0．001；r=0．636，P〈0．001），而Pmax及PWD与LVEF均呈负相关（r=-0．672，P〈0．001；r=-0．746，P〈0．001）。结论：在扩张型心肌病患者中PWD明显延长，并与其心功能不全程度明显相关。

Relation between P-wave dispersion and dilated cardiomyopathy

Objective: To investigate P-wave dispersion(PWD) in patients with dilated cardiomyopathy. Methods:The study population consisted of 53 patients with dilated cardiomyopathy and 53 healthy control subjects.Maximum P-wave duration(Pmax) and minimum P-wave duration(Pmin) were measured from the 12-lead surface electrocardiogram.PWD was calculated as the difference between Pmax and Pmin.Left atrial diameter,left ventricular end-diastolic and end-systolic diameters and left ventricular ejection fraction of all patients and control subjects were measured by means of transthoracic echocardiography. Results:Pmax and PWD of patients with dilated cardiomyopathy were significantly higher than those of control subjects(P< 0.001).However,there was no statistically significant difference between patient group and control group regarding Pmin(P<0.05).Pmax and PWD were found to be positively correlated with left atrial diameter(r=0.533,P<0.001 and r=0.636,(P<)0.001)and negatively correlated with left ventricular ejection fraction(r=-0.672,P<0.001 and(r=)-0.746,P<0.001). Conclusion: PWD was found to be significantly higher in patients with dilated cardiomyopathy than in healthy control subjects.