Aggregation inhibitory activity of minor acetophenones from Paeonia species |
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| Authors: | Lin H C Ding H Y Ko F N Teng C M Wu Y C |
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| Affiliation: | School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. hcl@ndmcl.ndmctsgh.edu.tw |
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| Abstract: | ![]()
Two minor acetophenones, 2,5-dihydroxy-4-methoxy-acetophenone (2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA2 and PGD2 from arachidonic acid. |
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