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Magnesium restores high K-induced inactivation of the fast Na channel in guinea pig ventricular muscle
Authors:Tatsuto Kiyosue  Makoto Arita
Affiliation:(1) Department of Physiology, Faculty of Medicine Medical College of Oita, 879-56 Oita, Japan
Abstract:The effect of extracellular magnesium concentration (Mgo) on the upstroke of the action potential was studied in guinea pig ventricular muscle under various K+ concentrations (2.7–19mM). Increased Mgo shifted the steady state inactivation curve of the fast Na channel in the depolarizing direction and this effect was concentration-dependent (0–20mM). Such an effect could explain the Mg-induced increase in maximum rate of rise of the action potential which Späh and Fleckenstein (1979) proposed to be due to a ldquoMg channelrdquo.
Keywords:Magnesium  Ventricular muscle  Maximum rate of rise  Na inactivation curve  Surface charge
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