| 环维黄杨星D磺酰化衍生物的合成及耐缺氧活性的研究 |
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| 引用本文： | 郭彩红,窦后松,郜宁,肖佩玉,李颖,尹述凡. 环维黄杨星D磺酰化衍生物的合成及耐缺氧活性的研究[J]. 华西药学杂志, 2006, 21(6): 511-514 |
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| 作者姓名： | 郭彩红 窦后松 郜宁 肖佩玉 李颖 尹述凡 |
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| 作者单位： | 四川大学化学学院,四川,成都,610064;四川川大华西药业股份有限公司,四川,成都,610041;广州中心附属第三医院,广东,广州,510630 |
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| 摘 要： | 目的寻找更多具有治疗心脑血管疾病的潜在药物。方法通过磺酰化反应将不同取代的磺酰氯中间体连接到环维黄杨星D上,合成得到目标产物,并对其进行耐缺氧活性的研究。结果和结论共合成了7个环维黄杨星D磺酰化衍生物,其结构经IR、MS1、HNMR和高分辨质谱(HRMS)确证,且化合物2 a~2g均具有良好的药理活性,其中化合物2 e、2g作用最强,超过现有临床药物黄杨宁片。
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| 关 键 词： | 环维黄杨星D 磺酰化 结构修饰 合成 耐缺氧活性 |
| 文章编号： | 1006-0103(2006)06-0511-04 |
| 收稿时间： | 2006-04-01 |
| 修稿时间： | 2006-04-01 |
Synthesis and effects of sulfonamide derivatives of Cyclovirobuxine D on oxygen-deficient endurance in mice |
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| GUO Cai-hong,DOU Hou-song,GAO Ning,XIAO Pei-yu,LI Ying,YIN Shu-fan. Synthesis and effects of sulfonamide derivatives of Cyclovirobuxine D on oxygen-deficient endurance in mice[J]. West China Journal of Pharmaceutical Sciences, 2006, 21(6): 511-514 |
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| Authors: | GUO Cai-hong DOU Hou-song GAO Ning XIAO Pei-yu LI Ying YIN Shu-fan |
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| Affiliation: | 1. College of Chemistry, Sichuan University, Chengdu 610064, China; 2. Sichuan Chuanda West China Pharmaceuitical Co. , Lid, Chengdu 610041, China ; 3. The Third Affiliated Hospital of Sun Yat - sen University, Guangzhou 510630, China |
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| Abstract: | OBJECTIVE To obtain more potential agents for the treatment of cardiovascular diseases.METHODS The target compounds were synthesized from the corresponding sulfonic acid chloride and Cyclovirobuxine D by sulfonamide acylation.RESULTS and CONCLUSION The structures of all compounds synthesized were determined by IR,MS,()~1HNMR and HRMS.Their effects on oxygen-deficient endurance in mice were primarily evaluated.The results indicated that all compounds possess efficiency on oxygen-defecient endurance,especially that compounds 2e,2g were more active than clinical drug Cyclovirobuxinel tablet.These seven new compounds can promote the treatment capability of cardiovascular diseases. |
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| Keywords: | Cyclovirobuxine D Sulfonamide Structural modification Synthesis Oxygen-deficient endurance |
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