一氧化氮的肿瘤生物学效应

一氧化氮是人体内活跃的具有多种生物学活性的小分子物质，目前研究表明其在多种肿瘤组织内表达。从肿瘤生物学角度来看，一氧化氮可以体现出许多不同的、有时看来甚至是相互矛盾的生物学效应。这些不同的生物学效应与很多因素有关，其中最重要的是组织中一氧化氮的浓度。高浓度的一氧化氮可以介导肿瘤细胞的凋亡和抑制肿瘤生长；相对低浓度的一氧化氮可促使肿瘤生长和肿瘤细胞增殖，并可以使肿瘤细胞增强对放疗和某些化疗药物的耐受性。一氧化氮对肿瘤生长的双向调节作用为肿瘤的研究提供了一个新的方向。

Biological Effects of Nitric Oxide in Oncology

As a kind of small molecule with complex biological activities in human being,the expression of nitric oxide(NO) in various malignant tumor's tissues was proved in recent research.From perspective of oncology,NO could show the complexity,sometimes even contradictory biological effects.These different biological effects were relative to many factors.The most important factor was the concentration of NO in tissues.NO in high concentrations might mediates apoptosis in tumor cells and inhibits the growth of car...