Induction of resistance against Schistosoma mansoni infection by passive transfer of an IgG2a monoclonal antibody. |
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| Authors: | A M Attallah H Attia E M El-Nashar A Nawar K Abdel Kader H Ismail G El Ebeidy |
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| Affiliation: | Biotechnology Research Center, New Damietta City, Egypt. |
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| Abstract: | Monoclonal antibodies can confer resistance to schistosome infections. This has led to identification of several protective antigens. An IgG2a monoclonal antibody designated BRL4 mAb identified a 74-kDa antigen in antigenic extract of Schistosoma mansoni adult worms. The target antigen was localized in gut and tegument. In 3 passive transfer experiments, the BRL4 mAb conferred 51.6, 41.9 and 53.8% protection levels into female Swiss mice. Histopathological examination revealed a marked decrease in number, size, collagen and reticular fibers of the liver granulomas. Further experiments using purified 74-kDa-target antigen as a candidate vaccine will be performed. |
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