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Docetaxel neuropathy: a distal axonopathy |
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| Authors: | Raffaella Fazio A. Quattrini Angelo Bolognesi Gianni Bordogna Eugenio Villa Stefano Previtali Nicola Canal Raffaello Nemni |
| Affiliation: | (1) Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milan, Italy e-mail: quattrini.angelo@hsr.it Tel.: +39-02-26433036, Fax: +39-02-26432335, IT;(2) Department of Oncology, San Raffaele Scientific Institute, Milan, Italy, IT |
| Abstract: | Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal. Received: 21 January 1999 / Revised, accepted: 25 March 1999 |
| Keywords: | Neuropathy Docetaxel Paclitaxel Neurotoxicity Peripheral nerves |
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