NSCLC组织中nm-23和VEGF蛋白的表达及其临床意义

目的探讨非小细胞肺癌科scLc）组织中nm-23和VEGF蛋白的表达情况及其临床意义。方法通过免疫组化和组织芯片技术，分别检测208例NSCLC患者肿瘤组织、150例癌旁组织及17例良性疾病肺组织中nm-23和VEGF蛋白的表达状况。结果①NSCLC癌组织中nm-23蛋白的表达程度显著高于癌旁组织及良性肺疾病组织（P〈0．001）；nm-23蛋白表达程度与NSCL的C临床分期、分化程度相关（P〈0．05）。②NSCLC癌组织中VEGF蛋白表达程度显著高于癌旁组织及良性肺疾病组织（P＜0．001）；VEGF蛋白表达程度与NSCLC分化程度、临床分期和淋巴结转移与否相关（P〈0．05）。结论①NSCLC肿瘤组织中nm-23及VEGF蛋白均呈高表达，提示两者与NSCLC的发生发展密切相关；②NSCLC的临床分期及分化程度与nm-23蛋白表达程度相关。NSCLC的临床分期、分化程度及淋巴结转移与否与VEGF蛋白表达的程度相关，提示两者均与肿瘤恶性生物学行为密切相关。

Expression and significance of nm-23 and VEGF protein in the patients with non--small cell lung cancer.

Objective To study the expression and significance of nm-23 and vascular endothelial growth factor （VEGF） protein in patients with non-small cell lung cancer （NSCLC）. Methods The expression ofnm-23 and VEGF protein was detected in tumor tissues of 208 patients with NSCLC, adjacent tissues of 150 patients and lung tis- sues of 17 patients with benign lung disease by tissue microarray and immunohistochemistry. Results ① The expres- sion of nm-23 protein was significantly higher in NSCLC tumor tissues than that in adjacent tissues and benign lung tissues （P〈0.01）. The difference of nm-23 protein expression between different clinical stages and differentiations was significant （P〈0.05）. ② The expression of VEGF protein was significantly higher in NSCLC tumor tissues than that in adjacent tissues and benign lung tissues （P 〈0.01）. The difference of VEGF protein expression with different differenti- ations, clinical stages and lymph node metastasis was significant （P〈0.05）. Conclusion ① nm-23 and VEGF protein is highly expressed in NSCLC and associated with the development of NSCLC, so they can be used for early diagno- sis ofNSCLC; ② nm-23 protein is associated with the clinical stage and differentiation, and VEGF protein is associat- ed with the differentiation, clinical stage and lymph node metastasis.