补肾活血中药加克罗米芬治疗多囊卵巢综合征所致不孕的临床观察

目的：观察补肾活血中药加克罗米芬治疗多囊卵巢综合征(polycystic ovary syndrome，PCOS)所致不孕的临床疗效。方法：将排卵障碍所致不孕的62例PCOS患者随机分为治疗组(32例)与对照组(30例)，治疗组采用补肾活血中药加克罗米芬治疗，对照组采用剂量与治疗组相同的克罗米芬治疗。结果：治疗组治疗后内分泌激素水平较治疗前明显好转，雄激素、黄体生成素水平较治疗前明显下降。雌激素水平较治疗前明显升高(P<0．01)。治疗组的周期排卵率达87．0％，总妊娠率为65．6％，未发生卵泡过度刺激综合征(ovarian hyperstimulation syndrome，OHSS)及黄体化卵泡未破裂综合征(1uteinized unruptured follicle syndrome，LUFS)。而对照组周期排卵率为66．0％，总妊娠率36．6％．，有4例并发LUFS。两组疗效比较差异有显著性(P<0．05)。结论：补肾活血中药加克罗米芬治疗PCOS所致的不孕疗效明显高于单纯的克罗米芬治疗。

Clinical Observation on Treatment of Stein-Leventhal Syndrome Caused Sterility by Combined Use of Clomiphene and Chinese Nourishing Shen and Activating Blood Circulation Drugs

Objective:To observe the efficacy of combination therapy of clomiphene and Chinese drugs for nourishing Shen and activating blood circulation (NSABC) in treating Stein-Leventhal syndrome caused sterility. Methods:Sixty-two patients with anovulation caused sterility were randomly divided into the treated group (n=32) and the control group (n=30). The treated grop was treated with the combination therapy and the control group treated by the same dosage of clomiphene alone. Results:After treatment, when comparing with that before treatment, the endocrine hormones in the treated group improved significantly, showing a markedly decrease of androgen and luteotropic hormone, and increase of estrogen (P<0.001). The periodic ovulation rate in the treated group reached 87%, the total pregnancy rate being 65.6%, with no occurrence of ovarian hyperstimulation syndrome (OHSS) and luteinized unruptured follicle syndrome (LUFS), while in the control group, the periodic ovulation rate was 66%, the total pregnancy rate 36.6%, with LUFS occurred in 4 patients. Comparison of the therapeutic effects between the two groups showed significant difference (P<0.05). Conclusion:The combination therapy of clomiphene and NSABC has a better therapeutic effect in treating Stein-Leventhal syndrome caused sterility than that of using clomiphene alone.