缺血性脑血管病患者颈动脉病变与糖代谢的相关性研究

目的对缺血性脑血管病患者颈动脉病变与糖代谢相关性进行分析。方法观察对象选自2011年3月～2012年12月来我院就诊的234例缺血性脑血管病患者，以所有患者的检查结果及疾病史为依据将其分为3组：糖耐量正常组（NGT组）59例，合并糖耐量减低组（IGT组）85例，合并糖尿病组（T2DM组）90例。对患者的基本情况及生化指标等进行比较，影响因素的筛选采用多元线性回归进行分析。结果0）IGT组、T2DM组患者与NGT组比较，其具有明显较多的患者例数，具有较高的吸烟例数比例、合并高血压例数比例及具有较高的BMI、WHR及颈动脉粥样斑块积分（P〈0．05）；将T2DM组患者的以上观察指标与IGT组进行比较，其组间也具有显著性差异（P〈0．05）。②IGT组、T2DM组患者与NGT组比较，其FBG、PBG、CRP检测值明显较高（P〈0．05）；将T2DM组患者的以上生化指标与IGT组进行比较，其组间也具有显著性差异（P〈0．05）。③缺血性脑血管病颈动脉病变的影响因素如下：高血压、吸烟、FBG、PBG、CRP、BMI、WHR。结论颈动脉病变发生过程中糖代谢异常为其独立危险因素，影响颈动脉病变的危险因素还包括高血压、吸烟、BMI、WHR、CRP。

Study on relationship between carotid artery atherosclerosis and glucose metabolism in patients with ischemic cere- brovascular disease

Objective To analyze the relationship between carotid artery atherosclerosis and glucose metabolism in pa- tients with ischemic cerebrovascular disease. Methods 234 patients with ischemic cerebrovaseular disease were selected from Mar 2011 to Dec 2012 in our hospital as the observation, they were divided into three groups followed all the examination results and disease history：NGT group（59 cases）, IGT group（85 cases）, T2DM group（90 cases）. Compared the basic conditions of the patients and biochemical indicators, affecting factors were analyzed with muhiple linear regression analysis. Results （!）Com- pared with NGT group, the number of patients in IGT group and T2DM group were significantly more, had a higher proportion of smoking, hypertension and BMI, WHR and carotid artery plaque score were higher （P〈0.05）; T2DM group patients with the above observation indexes were compared with the IGT group, it also had significant difference （P〈0.05）. （~）Compared with NGT group, the FBG, PBG, CRP, carotid artery plaque integral detection values in IGT group and T2DM group were signifi- cantly higher （P〈0.05） ; there were significant difference in above biochemical index between T2DM group and IGT group （P〈 0.05）. （~The following factors influenced the lesion of carotid artery ischemic cerebrovascular diseases： hypertension, smoking, FBG, PBG, CRP, BMI, WHR. Conclusion Place sugar metabolic disease is the independent risk factors of carotid artery disease, risk factors include hypertension, smoking, BMI, WHR, CRP.