发热及小儿解热药的使用

发热是对抗疾病的一种复杂生理学反应,涉及细胞因子介导的体温升高,急性期反应物的生成,内分泌和免疫学系统的激活。内生性致热原和众多体温中枢调节介质构成了一个复杂的体温调节网络,负责机体的体温调节平衡。发热是小儿临床中最常见的症状之一,目前临床中使用的小儿解热药大多具有副作用,所以了解发热的基本机制,开发安全有效的小儿解热药具有重要的临床意义。

Fever Pathogenesis and Antipyretic Use in Children

As one of the most common symptoms in children, fever is a complex physiological response to diseases, involving with elevation of body temperature mediated by cytokines, generation of acute phase reactants as well as the activation of numerous endocrinology and immunology systems. Endogenous pyrogenic and mediators in the thermoregulation center comprise a complicated thermoregulatory network, contributing to the thermoregulatory balance. Given the adverse drug reactions concerning the current applied antipyretics in children, it is of great clinical significance to understand the mechanisms underlying fever and develop children antipyretics with more safety and higher efficacy.