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Ecto-F_1-ATPase: A moonlighting protein complex and an unexpected apoA-I receptor |
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| Authors: | Pierre Vantourout Claudia Radojkovic Laeticia Lichtenstein Véronique Pons Eric Champagne Laurent O Martinez |
| Affiliation: | Pierre Vantourout; Claudia Radojkovic; Laeticia Lichtenstein; Véronique Pons; Eric Champagne; Laurent O Martinez; Institut national de la santé et de la recherche médicale U1048; Toulouse; F-31000; France Institute of Metabolic and Cardiovascular Diseases; Université Toulouse III Paul-Sabatier; F-31300; France; |
| Abstract: | Mitochondrial ATP synthase has been recently detected at the surface of different cell types, where it is a high affinity receptor for apoA-I, the major protein component in high density lipoproteins (HDL). Cell surface ATP synthase (namely ecto-F1-ATPase) expression is related to different biological effects, such as regulation of HDL uptake by hepatocytes, endothelial cell proliferation or antitumor activity of Vγ9/Vδ2 T lymphocytes. This paper reviews the recently discovered functions and regulations of ... |
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