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| CCNG2在鼻咽癌中的表达及其临床意义 | |
| 引用本文： | 孙国贵,崔大为,程云杰. CCNG2在鼻咽癌中的表达及其临床意义[J]. 肿瘤学杂志, 2014, 20(4): 316-319 |
| 作者姓名： | 孙国贵 崔大为 程云杰 |
| 作者单位： | 唐山市人民医院;唐山市工人医院;河北医科大学第四医院 |
| 摘 要： | [目的]探讨细胞周期蛋白G2（CCNG2）在鼻咽癌中的表达及其意义。[方法]采用免疫组织化学方法、WesternBlot检测87例鼻咽癌组织和34例正常鼻咽组织中CCNG2蛋白的表达情况。[结果]免疫组织化学结果表明，CCNG2蛋白在鼻咽癌组织及正常鼻咽组织中的表达阳性率分别为37．9％、91．2％．差异有统计学意义（P〈0．05）。WesternBlot结果表明，CCNG2的蛋白在鼻咽癌组织的相对表达量较正常鼻咽组织明显降低．差异亦具有统计学意义（P〈0．05）。CCNG2蛋白表达与鼻咽癌T分期、临床分期及分化程度有关（P〈0．05）。[结论]鼻咽癌组织中CCNG2蛋白表达明显减低，且与鼻咽癌T分期、临床分期及肿瘤分化有关。 |
| 关 键 词： | CCNG2 鼻咽肿瘤 预后 肿瘤转移 |
| 收稿时间： | 2013-09-10 |
Expression of CCNG2 in Nasopharyngeal Cancer and Its Significance |
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| Affiliation: | SUN Guo-gui, CUI Da-wei, CHENG Yun-jie, et al. ( 1.Tangshan People＇s Hospital, Tangshan 063000, China;2.Tangshan Works Hospital, Tangshan 063000, China; 3. The Fourth Hospital of Hebei Medical University ,Shijiazhuang 050017, China) |
| Abstract: | [Purpose ] To investigate the expression of Cyclin G2（CCNG2） in nasopharyngeal car- cinoma and its clinical significance. [Methods] Immunohistochemistry and Western Blot assays were used to analyze CCNG2 protein expression in 87 samples of nasopharyngeal cancer tissue and 34 samples of normal nasopharyngeal tissue. [Results] The positive rate of CCNG2 protein expression was significantly lower in nasopharyngeal cancer tissues than that in normal tissues （P〈0.05）. The relative amount of CCNG2 protein in nasopharyngeal cancer tissues was signifi- cantly lower than that in normal tissues （P〈0.05）. The expression of CCNG2 protein correlated to T stage,clinic stage and histological grade （P〈0.05）. [Conclusionl CCNG2 expression is low in nasopharyngeal cancer and correlates to T stage, clinic stage and histological grade. |
| Keywords: | CCNG2 nasopharyngeal neoplasms prognosis tumor metastasis |
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