| 别嘌呤醇致药物超敏综合征三例报告并文献复习 |
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| 引用本文： | 陈燕,朱晓雷,盛梅笑,赵建学. 别嘌呤醇致药物超敏综合征三例报告并文献复习[J]. 临床误诊误治, 2015, 0(1): 76-79 |
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| 作者姓名： | 陈燕 朱晓雷 盛梅笑 赵建学 |
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| 作者单位： | 1. 江苏省中医院 南京中医药大学附属医院肾内科, 南京,210029
2. 江苏省中医院 南京中医药大学附属医院感染科, 南京,210029 |
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| 摘 要： | 目的探讨别嘌呤醇致药物超敏综合征(drug rash with eosinophilia and systemic symptoms,DRESS)的临床特点及治疗方法。方法回顾分析我院近年收治3例别嘌呤醇致DRESS的临床资料。结果本文3例因痛风或高尿酸血症服用别嘌呤醇后1~2周左右出现全身弥漫性皮疹伴发热、肝肾功能损伤、血液学改变,2例出现少尿,1例出现胆汁淤积性黄疸。经相关医技检查及病因排查均诊断为别嘌呤醇过敏,DRESS。3例均予糖皮质激素和(或)联合丙种球蛋白治疗,2例病情缓解,但糖皮质激素减量过程中出现病情反复,1例死亡;另1例病情恶化放弃治疗。结论别嘌呤醇致DRESS临床表现多样,早期大剂量糖皮质激素治疗可有效控制症状,病情缓解后糖皮质激素减量应缓慢,并警惕复发。
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| 关 键 词： | 别嘌呤醇 药物超敏综合征 药疹 药物毒性 误诊 |
Drug Hypersensitivity Syndrome Caused by Allopurinol:A Report of 3 Cases and Literature Review |
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| CHEN Yana,ZHU Xiao-leia,SHENG Mei-xiaoa,ZHAO Jian-xueb. Drug Hypersensitivity Syndrome Caused by Allopurinol:A Report of 3 Cases and Literature Review[J]. Clinical Misdiagnosis & Mistherapy, 2015, 0(1): 76-79 |
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| Authors: | CHEN Yana ZHU Xiao-leia SHENG Mei-xiaoa ZHAO Jian-xueb |
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| Affiliation: | CHEN Yan;ZHU Xiao-lei;SHENG Mei-xiao;ZHAO Jian-xue;Provincial Hospital of Traditional Chinese Medince of Jiangsu Province,Department of Nephrology;Provincial Hospital of Traditional Chinese Medince of Jiangsu Province,Department of Infectious Diseases; |
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| Abstract: | |
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| Keywords: | Allopurinol Drug hypersensitivity syndrome Drug rash Drug toxicity Misdiagnosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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