腮腺原发性恶性黑色素瘤临床病理观察

目的观察原发性恶性黑色素瘤的病理形态。方法标本采用组织病理学和免疫组化（S-100、HMB45、Male—A）进行观察。结果肿瘤组织位于腮腺一侧，瘤组织呈推挤性边缘浸润至腮腺组织中，瘤细胞分布弥散，有窦样血管及少许纤维间质分隔，瘤细胞有异型性，核异型明显，边缘区个别肿瘤细胞细胞质内及肿瘤间质内有棕黄褐色素颗粒。免疫组化：瘤细胞S-100、HMB-45及Male-A强阳性；NSE、Vimentin弱阳性；LCA、CD15、CD30、Cytokeratin、EMA、Desmin、SMA、PLAP、Synapsin及Chromogranin A均为阴性。结论腮腺原发性恶性黑色素瘤极为罕见，组织起源尚有争议，可能起源腮腺导管甚或腺泡中DOPA阳性细胞。

Clinical pathology observe of primary malignant melanoma of parotid gland

Objective To observe the clinical pathology form of primary malignant melanoma. Methods Specimens were observed by histopathology and immunohistopathologic (S-100, HMB-45, Male-A). Results Tumor islocated on the side, and infiltration of radiofrequent pushed its way to the edge of the Parotid gland tissue. the distribution of dispersoids tumor cells, there were sinusal-like vessel and a little fiber interstitialoma separated, tumor cells have multiformity, nuclear heterotype obvious, fringe cytoplasmic individual tumor cells and the tumor interstitialoma capsulelike brown yellow-brown pigment particles. Innunohistochemistry: The tumor cells were positive for S-100, HMB-45 and Amale-A, weak positive for NSE, Vimentin, but negative for LCA,CD15, CD30, Cytokeratin, EMA, Desmin, SMA, PLAP, Synapsin and Chromogranin A. Conclusion Primary malignant melanoma of the Parotid gland is extremely rare, its histogenesis was disputed, may be the origin of the parotid duct or even DOPA-positive cells in aciner.