乙型肝炎病毒前S_1抗原在乙型肝炎诊断中的意义

目的探讨Pre S1-Ag在乙型肝炎诊断中的意义。方法采用酶联免疫法检测464例乙型肝炎患者血清标志物(HBV-M)和乙型肝炎前S1抗原(PreS1-Ag)采用荧光定量PCR法同时检测HBVDNA,分析PreS1-Ag与血清HBV-M和HBVDNA的关系。结果 HbeAg阳性的两组中,PreS1-Ag阳性率分别为88.62%和74.19%,HBVDNA的阳性率分别为94.01%和83.87%与:HbeAg呈明显的正相关,三者间差异无统计学意义(χ2=1.87,P<0.05)。结论 PreS1-Ag能敏感地反映出HBV复制与HBVDNA的一致性较好,在乙型肝炎诊断和治疗中具有重要临床意义。

The Significance of Pre S1-Antigen of Hepatitis B in the Diagnosis of Hepatitis B

Objective To evaluate the significance ofPre S：Ag in the diagnosis of ttepatitis B. Method Enzyme linked Immunoassay method was used to detect HBV-M of HBV serum markers from 580 cases and Pre- S lAg .The HBV DNA was detected by PCR. The relationships of PreS 1-Ag and HBV-M or HBVDNA were analyzed. Result PreS1-Ag positive rates of patients with HBeAg positive from two groups were 88.62% and 74.19%, and HBeAb positive patients were 94. 01% and 83.87%.HBVDNA was positively related to HbeAg.There was no significant difference between the three. （x2 =1.87, P〈0.05） . Conclusion PreS：Ag can sensitively reflect the replication of HBV and HBVDNA good consistency,and has important clinical significance in hepatitis B diagnosis and treatment.