Nitrite/nitrate (NOx) levels and hemodynamics during septic shock |
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| Authors: | Hajime Nakae Shigeatsu Endo Mitsuru Kikuchi Yasuhiko Yamada Masashi Shibata Hiroyasu Ishikura Takaya Tanaka Go Wakabayashi Takae Kawamura Katsuya Inada Seidai Sato |
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| Affiliation: | (1) Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan, JP;(2) Department of Emergency and Critical Care Medicine, Kansai Medical University, 10-12 Fumizonocho, Moriguchi, Osaka 570-0074, Japan, JP;(3) Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-0016, Japan, JP;(4) Memorial Heart Center, Iwate Medical University, 1-2-3 Chuodori, Morioka 020-0021, Japan, JP;(5) Department of Bacteriology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka 020-8505, Japan, JP |
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| Abstract: | ![]()
Nitric oxide (NO) acts as a vasorelaxant. We investigated the relationship between nitrite/nitrate (NOx), which are the final metabolites of NO, and hemodynamics during septic shock. We also examined tumor necrosis factor α (TNF-α), interleukin-8 (IL-8), and endotoxin. A significant negative correlation was observed between NOx levels and pulmonary capillary wedge pressure (PCWP; r = −0.6075, P = 0.0028). A significant positive correlation was noted between NOx levels and the cardiac index (CI; r = 0.5934, P = 0.0038). A significant negative correlation was found between NOx levels and the systemic vascular resistance index (SVRI; r = −0.4354, P = 0.0485). A significant positive correlation was observed between NOx levels and the stroke volume index (SVI; r = 0.5040, P = 0.0186). A significantly close positive correlation was also observed between TNF-α levels and NOx levels (r = 0.7848, P < 0.0001). These findings suggest that NOx levels are closely associated with hemodynamics during septic shock, resulting in a vascular relaxing effect. Received: July 6, 1999 / Accepted: March 24, 2000 |
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| Keywords: | Nitric oxide Septic shock Hemodynamics Tumor necrosis factor α Interleukin-8 |
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