中药联合前列地尔治疗慢性肾衰竭疗效观察

目的:观察中药联合前列地尔治疗慢性肾衰竭(CR F)的临床疗效及安全性。方法:将70例CR F患者随机分为对照组和治疗组,对照组在常规治疗的基础上加用前列地尔,治疗组在对照组基础上联合中药祛瘀泄浊方进行治疗。观察治疗前后临床症状、血肌酐、血尿素氮、血尿酸及内生肌酐清除率等指标的变化及不良反应的发生情况。结果:经治疗后,总有效率对照组为61.76%,治疗组为86.11%,治疗组疗效优于对照组(P0.05)。2组肌酐较治疗前均有下降(P0.05,P0.01),治疗组下降较对照组明显(P0.05);治疗组内生肌酐清除率较治疗前有所改善(P0.05)。2组均未发生严重的不良反应。结论:中药联合前列地尔治疗CR F,能够明显延缓肾功能衰竭的进展,安全有效。

Clinical Efficacy of Chinese Herbal Medicine Plus Alprostadil for Treatment of Chronic Renal Failure

Objective. The investigation on the clinical efficacy and safety of Chinese herbal medicine plus alprostadil for the treatment of chronic renal failure. Methods： Seventy CRF patients were randomly divided into control group and treatment group. The control group was given alprostadil injection on the ba- sis of conventional treatment, and the treatment group was given Chinese herbal medicine Quyuxiezhuo recipe based on the treatment for the control group. Before and after treatment, clinical symptoms, serum creatinine, blood urea nitrogen, blood uric acid and creatinine clearance rate as well as the inci- dence of adverse reaction in the two groups were recorded. Results： After treatment, the total effective rate was 61.76% in the control group and was 86.11% in the treatment group（P 〈 0.05）. Serum creatinine level was decreased in both groups（P 〈 0.05 compared with that before treatment）, and the decrease was obvious in the treatment group（P 〈 0.05）. Creatinine clearance rate was improved than before the treat- ment in treatment in treatment group（P 〈 0.05）. No severe adverse reaction was found in the two groups. Conclusion： Chinese herbal medicine plus alprostadil is effective and safe for the treatment of chronic re- nal failure, and can postpone the progress of renal failure.