| 阿维A对寻常性银屑病患者血清IL-18的影响 |
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| 引用本文： | 林玲,罗权,刘玉梅,何玉清,周欣,张锡宝. 阿维A对寻常性银屑病患者血清IL-18的影响[J]. 海南医学, 2009, 20(11): 4-5 |
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| 作者姓名： | 林玲 罗权 刘玉梅 何玉清 周欣 张锡宝 |
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| 作者单位： | 广东省广州市皮肤病防治所,广东,广州,510095;广东省广州市皮肤病防治所,广东,广州,510095;广东省广州市皮肤病防治所,广东,广州,510095;广东省广州市皮肤病防治所,广东,广州,510095;广东省广州市皮肤病防治所,广东,广州,510095;广东省广州市皮肤病防治所,广东,广州,510095 |
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| 基金项目： | 广东省内然科学基金,广州市医药卫生科研项目 |
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| 摘 要： | 目的研究IL-18在寻常性银屑病发病中的作用及阿维A对其的诃节作用,进一步探讨阿维A治疗银屑病的机制。方法应用双抗体夹心酶联免疫吸附法（ELISA）检测30例寻常性银屑病患者经阿维A治疗前后外周血IL-18的水平变化。结果寻常性银屑病患者经阿维A治疗前的血清中IL—18的水平显著高于治疗后及正常人对照组;治疗后血清中IL—18水平较治疗前显著下降（P〈0．05）。结论IL—18在寻常性银屑病致病中起重要作用;阿维A治疗银屑病的机制可能是通过抑制IL-18的分泌而达到治疗作用。
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| 关 键 词： | 阿维A 银屑病 白细胞介素18 |
Affection of acitretin on serum IL-18 in the patients with psoriasis vulgaris |
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| Affiliation: | LUO Quan,LI Chang- xing, LIU Yu -mei, et al.( Guangzhou Institute of Dermatology, Guangzhou 510095, Guangdong , P. R. CHINA) |
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| Abstract: | Objective To investigate the regulation of aeitretin on IL - 18 in the patients with psoriasis vulgaffs as well as explore its mechanism. Methods Levels of IL - 18 in sera were measured by double antibody sandwich enzyme - linked immunosorbent assay （ ELISA ） in 30 patients with psoriasis vulgaffs before and after treatment with acitretin. Results Compared with those in normal controls, the serum levels of IL - 18 in the patients with psoriasis vulgaris were significantly higher （ P 〈 0.05 ） ; after the treatment with acitretin, the serum levels of IL - 18 were statistiely decreased（ P 〈 0.05 ）. Conclusion IL - 18 plays an important role in the pathogenesis of psoriasis. It is indicated that inhibiting the secretion of IL - 18 may be involved in the mechanism of aeitretin to treat psoriasis vulgaris. |
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| Keywords: | Aeitretin Psoriasis vulgafis Interleukin- 18 |
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