利多卡因加地塞米松预防化疗所致静脉炎的临床研究

目的探讨利多卡因加地塞米松在预防癌症患者化疗所致静脉炎中的作用。方法选择150例静脉化疗三次以上的患者，随机分成治疗组（n=75）和对照组（n=75）。治疗组在化疗前后静脉滴注利多卡因2ml和地塞米松5mg，对照组在化疗同时用喜疗妥外涂穿刺血管；观察两组化疗后静脉炎发生情况。结果治疗组静脉炎发生率及疼痛程度均低于对照组，差异有统计学意义（14．66％比33．33％，13．33％比34．66％；均P〈0．01）。结论利多卡因加地塞米松可使化疗所致的静脉炎明显下降。

The effect of Lidocaine and Dexamethasone on reducing phlebitis caused by chemotherapy

Objective To investigate the effect of Lidocaine and Dexamethasone on reducing phlebitis caused by chemotherapy in cancer patients. Methods Totally 150 patients with chemotherapy for more than 3 times were randomly divided into two groups, the treatment group （ n = 75 ） and the control group （ n = 75 ） . Treatment group was used lidocaine 2ml and dexamethasone 5rag by intravenous infusion, while control group was smeared with Hirudoid along the puncture vein. The incidence of phlebitis after chemotherapy were monitored. Results The incidence of phlebitis and the levels of pain were significantly lower as compared to the control group （ 14. 66% vs 33.33% , 13.33% vs 34. 66 ; both P 〈 0. 01 ） . Conclusions Using Lidocaine and Dexamethasone can obviously decrease the phlebitis caused by chemotherapy.