| 上皮间质转化与肿瘤侵袭转移关系的研究进展 |
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| 引用本文： | 孙丹,辛彦.上皮间质转化与肿瘤侵袭转移关系的研究进展[J].现代肿瘤医学,2011,19(10):2088-2091. |
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| 作者姓名： | 孙丹 辛彦 |
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| 作者单位： | 中国医科大学附属第一医院肿瘤研究所胃肠肿瘤病理研究室,普通外科研究所肿瘤病理研究室,辽宁,沈阳,110001 |
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| 基金项目： | 国家自然科学基金，国家自然科学基金，国家自然科学基金，教育部高等学校博士学科点专项科研基，辽宁省高等学校攀登学者计划，沈阳市科学技术计划项目 |
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| 摘 要： | 上皮间质转化(epithelial-mesenchymal transition,EMT)是指上皮细胞失去极性,失去与基底膜的连接等上皮表型,通过特定程序转化为具有间质表型的生物学过程,从而获得了较高的迁移与侵袭、抗凋亡和降解细胞外基质的能力,与肿瘤的侵袭转移密切相关。参与这一过程的细胞内信号转导途径主要有:TGF-β信号途径、PI3K/AKT途径、Notch信号通路、Wnt信号通路等。本文就EMT在肿瘤侵袭转移中的作用及其分子机制的研究作一综述。
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| 关 键 词： | 上皮间质转化 信号通路 侵袭 转移 |
The research progress of the relation between epithelial-mesenchymal transition and tumor invasion or metastasis |
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| SUN Dan,XIN Yan.The research progress of the relation between epithelial-mesenchymal transition and tumor invasion or metastasis[J].Journal of Modern Oncology,2011,19(10):2088-2091. |
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| Authors: | SUN Dan XIN Yan |
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| Institution: | SUN Dan,XIN Yan Gastrointestinal Tumor Pathology Laboratory of Cancer Institute,Department of Tumor Pathology of General Surgery Institute,No.1 Hospital of China Medical University,Liaoning Shenyang 110001,China. |
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| Abstract: | Epithelial-mesenchymal transition(EMT) describes the loss of the epith-elial cell polarity and epithelial phenotype,such as the connections with the basement membrane.It is a biological process to express the mesenchymal phenotype through a specific program and gain the abilities of invasion,metastasis,anti-apoptosis and extracellular matrix degradation which are associated with the tumor invasion and metastasis.The cell signaling pathways involved in the process including TGF-β signaling pathway,PI3K/AKT pathway,Notch signaling pathway,Wnt signaling pathway and so on.This review summarizes the current progress in the research field of EMT and the role of EMT in tumor invasion and metastasis. |
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| Keywords: | epithelial-mesenchymal transitions signaling pathway invasion metastasis |
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