| 戈舍瑞林联合三苯氧胺治疗绝经前ER+PR+及ER+PR-复发转移性乳腺癌疗效观察 |
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| 引用本文： | 顾书成,管小青,吴骥,侍孝红,江小玲,陈焰,吴建强,吴际生,郑向欣,袁牧. 戈舍瑞林联合三苯氧胺治疗绝经前ER+PR+及ER+PR-复发转移性乳腺癌疗效观察[J]. 现代肿瘤医学, 2011, 19(9). DOI: 10.3969/j.issn.1672-4992.2211.09.18 |
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| 作者姓名： | 顾书成 管小青 吴骥 侍孝红 江小玲 陈焰 吴建强 吴际生 郑向欣 袁牧 |
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| 作者单位： | 1. 南京鼓楼医院集团宿迁市人民医院甲状腺、乳腺及内分泌外科,江苏,宿迁,223800
2. 南京鼓楼医院集团宿迁市人民医院病理科,江苏,宿迁,223800 |
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| 基金项目： | 江苏省卫生厅科技计划资助课题 |
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| 摘 要： | 目的:探讨戈舍瑞林联合三苯氧胺辅助内分泌治疗绝经前雌激素(ER)、孕激素(PR)双阳性及ER+/PR-两种复发转移乳腺癌的临床疗效,对比两种乳腺癌的治疗效果.方法:将104例绝经前、原癌基因(c-erbB-2)均为(+)、淋巴结1-3个阳性的复发转移乳腺癌患者分成两组,52例ER+/PR+,52例为ER+/PR-.两组患者均为手术后和辅助化疗后发现复发转移的乳腺癌接受戈舍瑞林3.6mg皮下注射,每28天1次,连续6个月以上;联合三苯氧胺口服,10mg/次,每日2次,连用6个月以上.结果:104例患者完全缓解(CR)3例,部分缓解(PR)31例,稳定(SD)31例,进展(PD)39例,总有效率(OR=CR+PR)为32.7%,临床获益率(CBR=CR+PR+SD≥6个月)62.5%;其中ER+、PR-组,CR 2例,PR 21例,SD 16例,PD 13例,OR为44.1%,CBR 74.9%;ER+、PR-组CR 1例,PR 10例,SD 15例,PD 26例,OR 21.1%,CBR 49.9%.结论:戈舍瑞林联合三苯氧胺辅助内分泌治疗绝经前ER阳性、淋巴结1-3阳性、复发转移性的乳腺癌患者临床疗效显著,而ER+/PR+组患者效果明显优于ER+、PR-组患者,临床治疗效果更佳.对于在辅助内分泌治疗期间发生PD,应立即中止辅助内分泌治疗,进行手术、解救化疗、放疗或分子靶向等治疗后再序贯内分泌治疗.
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| 关 键 词： | 绝经前乳腺癌 ER阳性 戈舍瑞林 三苯氧胺 复发转移 辅助内分泌治疗 |
Clinical therapeutic effect of goserelin combining tamoxifen assisting endocrine treatment on premenopausal ER+PR+and ER+PR-recurrent metastatic breast cancer |
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| GU Shucheng,GUAN Xiaoqing,WU Ji,SHI Xiaohong,JIANG Xiaoling,CHEN Yan,WU Jianqiang,WU Jisheng,ZHENG Xiangxin,YUAN Mu. Clinical therapeutic effect of goserelin combining tamoxifen assisting endocrine treatment on premenopausal ER+PR+and ER+PR-recurrent metastatic breast cancer[J]. Journal of Modern Oncology, 2011, 19(9). DOI: 10.3969/j.issn.1672-4992.2211.09.18 |
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| Authors: | GU Shucheng GUAN Xiaoqing WU Ji SHI Xiaohong JIANG Xiaoling CHEN Yan WU Jianqiang WU Jisheng ZHENG Xiangxin YUAN Mu |
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| Affiliation: | GU Shucheng1,GUAN Xiaoqing1,WU Ji1,SHI Xiaohong2,JIANG Xiaoling2,CHEN Yan1,WU Jianqiang1,WU Jisheng1,ZHENG Xiangxin1,YUAN Mu1 1Department of Breast Surgery,2Department of Pathology,Suqian People Hospital of Nanjing Drum-towl Hospital Group,Suqian 223800,China. |
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| Abstract: | Objective:To explore the clinical curative effect on goserelin combining tamoxifen assisting endocrine treatment on premenopausal ER+/PR+and ER+/PR-recurrent metastatic breast cancer and compare the treatment effect.Methods:The 104 recurrent metastatic breast cancer patients who were premenopausal,proto-oncogene(c-erbB-2)(+) and 1-3 lymph nodes(+) were divided into 52 ER+/PR+and 52 ER+/PR-.Both groups were diagnosed recurrent metastatic breast cancer after surgery and assisting chemotherapy treatment.The tw... |
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| Keywords: | premenopausal breast cancer ER( ) goserelin tamoxifen recurrent metastatic assisting endocrine treatment |
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