| 乳腺肿瘤CD44V6的表达及意义 |
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| 引用本文： | 陈文有,周松,李冉冉,邹耀祥.乳腺肿瘤CD44V6的表达及意义[J].现代肿瘤医学,2011,19(9):1759-1761. |
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| 作者姓名： | 陈文有 周松 李冉冉 邹耀祥 |
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| 作者单位： | 厦门大学附属东南医院,福建,漳州,363000 |
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| 摘 要： | 目的:探讨乳腺肿瘤中CD44V6(细胞粘附分子44变异体6)的表达及其与乳腺良恶性肿瘤、乳腺癌淋巴结转移和预后的关系。方法:免疫组化检测90例乳腺癌(淋巴结转移阳性45例,阴性45例)和20例乳腺纤维腺瘤中CD44V6的表达,分析CD44V6的表达与乳腺肿瘤良恶性的鉴别、乳腺癌患者淋巴结转移及预后的关系。结果:乳腺癌组CD44V6阳性表达率为71.1%,显著高于乳腺纤维腺瘤组15%;伴淋巴结转移组CD44V6阳性表达率为88.9%,显著高于无淋巴结转移组53.3%;不同病理分型乳腺癌中CD44V6阳性表达率差异无统计学意义;不同临床分期和生存期乳腺癌中CD44V6的阳性表达率显著不同。结论:CD44V6在乳腺良恶性肿瘤的鉴别、乳腺癌淋巴结转移与否的判断和预后评估等方面有一定意义。
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| 关 键 词： | 乳腺肿瘤 CD44V6 免疫组化 淋巴结转移 |
Expression and significance of CD44V6 in breast tumor |
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| CHEN Wenyou,ZHOU Song,LI Ranran,ZOU Yaoxiang.Expression and significance of CD44V6 in breast tumor[J].Journal of Modern Oncology,2011,19(9):1759-1761. |
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| Authors: | CHEN Wenyou ZHOU Song LI Ranran ZOU Yaoxiang |
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| Institution: | CHEN Wenyou,ZHOU Song,LI Ranran,ZOU YaoxiangAffiliated Dongnan Hospital of Xiamen University,Fujian Zhangzhou 363000,China. |
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| Abstract: | Objective:To investigate the expression of CD44V6 in breast tumor and its significance.Methods:The expression of CD44V6 in 90 breast carcinoma tissues(45 with lymph node metastasis,other 45 without) and 20 fibroadenoma of breast were studied by immunochemical envison methods.Results:Positive expression of CD44V6 in breast carcinoma was 75.6%,significantly higher than fibroadenoma of breast.Positive expression of CD44V6 in breast carcinoma with lymph node involvement was 88.9%,significantly higher than breas... |
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| Keywords: | breast tumor CD44V6 immunochemistry lymph node involvement |
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