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| 修复基因XRCC1 Arg194Trp位点多态性与肝癌易感性的关系 | |
| 引用本文： | 薄挽澜,张贵贤,李冬月,王玺,梁桃.修复基因XRCC1 Arg194Trp位点多态性与肝癌易感性的关系[J].现代肿瘤医学,2011,19(9):1724-1726. |
| 作者姓名： | 薄挽澜 张贵贤 李冬月 王玺 梁桃 |
| 作者单位： | 1. 哈尔滨医科大学第一临床医学院,黑龙江,哈尔滨,150001 2. 天津市传染病院,天津,300192 3. 哈尔滨医科大学第四临床医学院,黑龙江,哈尔滨,150001 |
| 基金项目： | 黑龙江省教育厅课题基金资助项目，黑龙江省卫生厅科研基金资助项目，哈尔滨医科大学第一临床医学院科研基金资助项目 |
| 摘 要： | 目的:探讨DNA损伤修复基因XRCC1多态与肝癌遗传易感性的关系。方法:本研究选取了130例肝癌患者及130例性别、年龄相匹配的正常对照者进行研究,采用限制性片段长度多态性方法,比较不同基因型与肝癌发病的关系。结果:变异型等位基因XRCC1 Arg/Trp及Trp/Trp的出现率在肝癌组和对照组中分别是27.69%和10.77%,(P<0.05);而野生基因型XRCC1 Arg/Arg出现率在肝癌组和对照组中分别是72.31和89.23%,(P>0.05)。结论:XRCC1基因Arg194Trp位点单核苷酸多态在肝癌的发生过程中起着至关重要的作用。 |
| 关 键 词： | 肝癌 修复基因 XRCC1 基因多态性 易感性 |
Polymorphisms of DNA repair gene XRCC1 and susceptibility to hepatic cancer |
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| BO Wanlan,ZHANG Guixian,LI Dongyue,WANG Xi,LIANG Tao.Polymorphisms of DNA repair gene XRCC1 and susceptibility to hepatic cancer[J].Journal of Modern Oncology,2011,19(9):1724-1726. | |
| Authors: | BO Wanlan ZHANG Guixian LI Dongyue WANG Xi LIANG Tao |
| Institution: | BO Wanlan1,ZHANG Guixian2,LI Dongyue1,WANG Xi1,LIANG Tao3 1The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China,2Infectious Diseases Hospital in Tianjin,Tianjin 300192,3The Fourth Affiliated Hospital of Harbin Medical University,China. |
| Abstract: | Objective:XRCC1(X-Ray repair cross-complementing group1)gene is one of the most important DNA repair gene systems,which maintains the integrity and stability of genome and prevents carcinogenesis.In this hospital-based case control study,we evaluated the association between polymorphisms XRCC1 and the risk of hepatic cancer.Methods: We genotyped the two polymorphisms by using polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP) in 130 confirmed hepatic cancer patients and 130 gender... |
| Keywords: | hepatic cancer DNA repairs XRCC1 polymorphism susceptibility |
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