曲美他嗪与低分子肝素治疗不稳定型心绞痛临床观察

目的:观察低分子肝素与曲美他嗪治疗不稳定型心绞痛(UAP)的疗效。方法:172例UAP患者随机分为2组,其中对照组88例;两组均常规给予硝酸酯类、β-受体阻滞剂及阿司匹林等;治疗给予低分子肝素钠4000 IU,2次/d,皮下注射,连用5~7d,加用曲美他嗪20?,每日3次及心电图改变情况。结果:治疗组临床总有效率为90.91%,对照组总有效率为69.05%,治疗组明显优于对照组(P<0.01)。治疗后治疗组ST段下降导联数(NST)ST段下降的数值总和(ΣST)及心肌缺血总负荷均较治疗前显著改善(P<0.01)。治疗组有5例皮下瘀斑,2例进展为AM I;而对照组有8例进展为AM I。结论:低分子肝素联用曲美他嗪,治疗UAP安全有效。

Clinical Observation of Low Molecular Weight Heparin Combined with trimetazidine on the Treatment of Unstable Angina Pectoris

Objective: To observe the effect of low molecular weight heparin combined with trimnetazidine on the treatment of unstable angina pectoris(UAP).Method: Eightysix patients with UAP were divided into two groups.There were 84 patients in the treatment group and 88 patients in the control group.Allof them were given the nitroglycerin,beta-blockers and aspirinetc.Treatment group were used the low molecular weight heparin 4000IU,twice a day hypodermic,after five to seven days,added the trimetazidine 20 mg,three times a day,it was used 15 days.The control group was used heparin sodium 5000IU,twice a day hypodermic,it was used five to seven days.Result: The total effective rate of the treatment group was 90.91% and the control group was 69.05%,the treatment group was much better than the control group(P<0.01).The treatment group contained 5 cases of subcutaneous purpura,and only 2 patients witn AMI,but the control group has 8 patients with AMI.All the patients were treated with coronary interventional therapy.Conclusion: The low molecular weight heparin combined with trimteazidine is more safety and effectively on UAP.