| 大鼠创伤性休克后血清一氧化氮的动态变化及其机制 |
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| 引用本文： | 冯浩淼,黄宗海,黄绪亮,宋慧娟,孙英刚,林洪武.大鼠创伤性休克后血清一氧化氮的动态变化及其机制[J].南方医科大学学报,2002,22(10):891-894. |
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| 作者姓名： | 冯浩淼 黄宗海 黄绪亮 宋慧娟 孙英刚 林洪武 |
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| 作者单位： | 1. 第一军医大学,珠江医院普通外科,广东广州,510282
2. 第一军医大学,全军休克微循环重点实验室,广东广州,510515 |
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| 基金项目： | 广东省自然科学基金(001048) |
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| 摘 要： | 目的探讨创伤性休克后血清一氧化氮(NO)浓度的动态变化及其机制。方法通过外力致鼠双侧后肢骨折,制作创伤性休克模型,Griess法测定休克过程中多时间点血清NO3-/ NO2-浓度。结果休克过程中血清NO无明显变化,复苏后早期(1 h)显著下降,6 h达峰值,其后血清NO维持较高水平,24 h仍显著升高。休克未复苏鼠血清NO无显著变化。结论创伤性休克时血中NO无显著变化,复苏后先有一过性NO减少,继而血中NO升高,持续至24 h,再灌注损伤是复苏后期NO合成增多的重要原因。
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| 关 键 词： | 休克 创伤性 一氧化氮 |
| 文章编号： | 1000-2588(2002)10-0891-04 |
| 修稿时间： | 2002年6月6日 |
Dynamic changes in serum level of nitric oxide and its mechanisms in rats with traumatic shock |
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| FENG Hao-miao ,HUANG Zong-hai ,HUANG Xu-liang ,SONG Hui-juan ,SUN Ying-gang ,Lin Hong-wu.Dynamic changes in serum level of nitric oxide and its mechanisms in rats with traumatic shock[J].Journal of Southern Medical University,2002,22(10):891-894. |
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| Authors: | FENG Hao-miao HUANG Zong-hai HUANG Xu-liang SONG Hui-juan SUN Ying-gang Lin Hong-wu |
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| Institution: | FENG Hao-miao 1,HUANG Zong-hai 1,HUANG Xu-liang 2,SONG Hui-juan 1,SUN Ying-gang 1,Lin Hong-wu 11 Department of General Surgery,Zhujiang Hospital,First Military Medical University,Guangzhou 510282,China, |
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| Abstract: | Objective To investigate the dynamic changes of serum nitric oxide (NO) level and its mechanisms in rats in traumatic shock. Methods Rat models of traumatic shock were established by fracturing the posterior limb of the rats. Serum levels of nitrate/nitrite were measured with the method described by Griess. Results No significant changes in serum NO level took place during traumatic shock. One hour after resuscitation, however, serum NO level first underwent marked decline and then increased to the peak level at 6 h after resuscitation, retaining a high level till 24 h after resuscitation. No obvious changes of serum NO levels were observed in rats without resuscitation. Conclusion Serum NO level does not significantly alter during traumatic shock, while after resuscitation, NO level increases after transient decrease, possibly due to reperfusion injury. |
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| Keywords: | shock traumatic nitric oxide |
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