| 99mTc-HL91显像在缺血性脑血管病中脑乏氧组织的应用研究 |
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| 引用本文： | 林伟,邬恒夫,武兆忠,邓力平,刘影,吴长伟,丁志辉.99mTc-HL91显像在缺血性脑血管病中脑乏氧组织的应用研究[J].国际放射医学核医学杂志,2008,32(3). |
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| 作者姓名： | 林伟 邬恒夫 武兆忠 邓力平 刘影 吴长伟 丁志辉 |
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| 作者单位： | 广州医学院第二附属医院核医学科,510260 |
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| 基金项目： | 广东省医药卫生科研项目，广州医学院校科研和教改项目 |
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| 摘 要： | 目的 探讨99mTc-4,9-二氮.3,3,10,10-四甲基十二烷-2,11-二酮肟(99mTc-HL91)在缺血性脑血管病中脑乏氧组织的临床应用价值.方法 对9例对照组和17例急性脑梗死患者于起病7 d内进行脑乏氧显像,同时进行了CT或MRI检查.其中2例分别于第一次显像阳性后9 d和12 d进行第二次乏氧显像.结果 对照组未见脑实质有明显核素浓聚,左侧,右侧比值为0.98±0.04.17例急性脑梗死患者中,乏氧显像阳性11例,阳性率64.7%,其患侧/健侧比值为1.54±0.55,与对照组比较有显著性差异(t=3.081,P＜0.05).结论 99mTc-HL91显像可以区分乏氧与坏死的脑组织,对指导治疗、评价疗效有一定的临床意义.
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| 关 键 词： | 脑梗死 细胞低氧 缺血缺氧 脑 体层摄影术 发射型计算机 单光子 |
Preliminary study on detection of brain hypoxic tissue in the patients with ischemic cerebrovascular of brain using 99mTc-HL91 imaging |
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| LIN Wei,WU Heng-fu,WU Zhao-zhong,DENG Li-ping,LIU Ying,WU Chang-wei,DING Zhi-hui.Preliminary study on detection of brain hypoxic tissue in the patients with ischemic cerebrovascular of brain using 99mTc-HL91 imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(3). |
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| Authors: | LIN Wei WU Heng-fu WU Zhao-zhong DENG Li-ping LIU Ying WU Chang-wei DING Zhi-hui |
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| Abstract: | Objective To investigate the detection of brain hypoxic tissue in patients with ischemic cerebrovaseular of brain using 99mTc-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime(99mTc-HL91)maging.Methods Nine controls and 17 patients with acute infarction of brain underwent 99mTc-HL91 imaging.Results The ratios of left/fight in controls is 0.98±0.04.The ratios of L/N in patients is 1.54±0.55.Conclusion 99mTc-HL91 imaging could detect brain hypoxie tissue after ischemic cerebrovascular of brain. |
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| Keywords: | Brain infarction Cell hypoxia Hypoxia-ischemia brain Tomography emissioncomputed single |
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