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| 石丹颗粒中挥发油包合工艺优选 | |
| 引用本文： | 徐佳,黄一平,王丽,姜梦华. 石丹颗粒中挥发油包合工艺优选[J]. 中国实验方剂学杂志, 2015, 21(1): 32-34 |
| 作者姓名： | 徐佳 黄一平 王丽 姜梦华 |
| 作者单位： | 1. 南京中医药大学药学院,南京 210023;江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,南京 210028 2. 江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,南京,210028 3. 南京中医药大学药学院,南京,210023 |
| 摘 要： | 目的:优选石丹颗粒中挥发油的包合工艺,为该制剂的临床应用与推广提供参考。方法:以挥发油包封率和包合物得率为综合评价指标,通过单因素试验比较饱和水溶液法和研磨法对包合效果的影响,采用正交试验考察挥发油与β-环糊精(β-CD)的投料比、加水量和研磨时间对包合工艺的影响,挥发油包合物进行TLC鉴别、UV鉴别、显微鉴别及稳定性考察。结果:采用研磨法包合,最佳包合工艺为β-CD与挥发油的投料比8∶1,加3倍量水研磨3 h;挥发油包封率87.04%,包合物得率89.12%。β-CD包合物在第0,1,3天的挥发油保留率分别为100%,89.23%,78.46%。结论:挥发油进入了β-CD空腔中形成相对稳定的β-CD包合物,制剂的稳定性显著提高。优选的包合工艺稳定可行,适合石丹颗粒的工业大生产。 |
| 关 键 词： | 石丹颗粒 挥发油 包合 β-环糊精 研磨法 |
| 收稿时间： | 2014-05-22 |
Optimization of Inclusion Process of Volatile Oil in Shidan Granules |
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| XU Ji,HUANG Yi-ping,WANG Li and JIANG Meng-hua. Optimization of Inclusion Process of Volatile Oil in Shidan Granules[J]. China Journal of Experimental Traditional Medical Formulae, 2015, 21(1): 32-34 | |
| Authors: | XU Ji HUANG Yi-ping WANG Li JIANG Meng-hua |
| Affiliation: | School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China |
| Abstract: | |
| Keywords: | Shidan granules volatile oil inclusion β-cyclodextrin trituration method |
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