Agouti-related peptide-expressing neurons are mandatory for feeding |
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| Authors: | Gropp Eva Shanabrough Marya Borok Erzsebet Xu Allison W Janoschek Ruth Buch Thorsten Plum Leona Balthasar Nina Hampel Brigitte Waisman Ari Barsh Gregory S Horvath Tamas L Brüning Jens C |
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| Institution: | Institute for Genetics and Center for Molecular Medicine (CMMC), Department of Mouse Genetics and Metabolism, University of Cologne, Zülpicher Str. 47, 50674 K?ln, Germany. |
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| Abstract: | Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis. |
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