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Non-motor symptoms are relevant and possibly treatable in hereditary spastic paraplegia type 4 (SPG4)
Authors:Rattay  Tim W.  Boldt  Andreas  Völker  Maximilian  Wiethoff  Sarah  Hengel  Holger  Schüle  Rebecca  Schöls  Ludger
Affiliation:1.Department of Neurodegenerative Disease, Hertie-Institute for Clinical Brain Research, and Center for Neurology, University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany
;2.German Center of Neurodegenerative Diseases (DZNE), Tübingen, Germany
;
Abstract:Journal of Neurology - Hereditary spastic paraplegias (HSP) share as cardinal feature progressive spastic gait disorder. SPG4 accounts for about 25% of cases and is caused by mutations in the SPAST...
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