鼠神经生长因子治疗糖尿病周围神经病变的疗效观察

目的:观察鼠神经生长因子治疗糖尿病周围神经病变(diabetic perineuropathy heuropathy,DPN)的临床疗效。方法:65例DPN患者随机分为A、B两组,A组为鼠源性神经生长因子治疗组,B组为甲钴胺治疗组,观察两组治疗前、后的临床疗效;神经运动传导速度(MNCV)、神经感觉传导速度(SNCV)的改善情况及不良反应发生情况。结果:A组总有效率为81.82%,高于B组(59.38%),差异具有统计学意义(P<0.01);两组治疗后MNCV、SNCV较治疗前均改善,差异有统计学意义(P<0.05);治疗后A组改善情况优于B组,差异有统计学意义(P<0.01)。结论:鼠神经生长因子治疗糖尿病周围神经病变疗效确切,是治疗糖尿病周围神经病变的一种较好方法,值得在临床推广应用。

Clinical Observation of Mouse Nerve Growth Factor Treating Diabetic Peripheral Neuropathy

Objective:To observe the efficacy of the mouse nerve growth factor(NGF) treating diabetic peripheral neuropathy(DPN).Methods:65 patients with DPN were randomly divided into two groups(A and B group),A group was given to mNGF,B group was given to mecobalamin only.Observing the clinical efficacy,the improving condition of MNCV and SNCV before and after curation.Results:The efficacy of A group was highter than that of B group(P<0.01),the MNCV and SNCV of A and B group become faster after curation(P<0.05),the nerve conduction velocity of A group was higher than B group(P<0.01).Conclusion:Mouse nerve growth factor combining with mecobalamin is safty and effective to the treatment of diabetic peripheral neuropathy.