| 固相萃取-LC-MS/MS测定鸡蛋中氟喹诺酮类药物残留 |
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| 引用本文： | 田 媛,张尊建,李 静,李文静,陈 沄.固相萃取-LC-MS/MS测定鸡蛋中氟喹诺酮类药物残留[J].中国药科大学学报,2010,41(1):60-65. |
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| 作者姓名： | 田 媛 张尊建 李 静 李文静 陈 沄 |
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| 作者单位： | 中国药科大学分析测试中心药物质量与安全预警教育部重点实验室;中国医学科学院皮肤病研究所; |
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| 摘 要： | 目的:建立同时测定鸡蛋中诺氟沙星、氧氟沙星、培氟沙星、环丙沙星、洛美沙星、达氟沙星、恩诺沙星、沙拉沙星、二氟沙星残留的固相萃取-LC-MS/MS测定方法。方法:鸡蛋样品经乙腈沉淀蛋白质和正己烷脱脂后,过HLB固相萃取小柱净化,LC-MS/MS分析,流动相为乙腈-0.1%甲酸(13∶87),色谱柱为岛津Shim-packVP-ODSC18柱。结果:建立的固相萃取-LC-MS/MS选择性好,灵敏度和准确度均良好。结论:建立的方法可作为多种药物残留检测的常规方法。
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| 关 键 词： | 氟喹诺酮 鸡蛋 多残留 LC-MS/MS 固相萃取 |
Multiresidue determination of fluoroquinolones in eggs by solid-phase extraction-LC-MS/MS |
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| TIAN Yuan,ZHANG Zun-jian,LI Jing,LI Wen-jing,CHEN Yun Key Laboratory of Drug Quality Control , Pharmacovigilance,Center for Instrumental Analysis,China Pharmaceutical University,Nanjing.Multiresidue determination of fluoroquinolones in eggs by solid-phase extraction-LC-MS/MS[J].Journal of China Pharmaceutical University,2010,41(1):60-65. |
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| Authors: | TIAN Yuan ZHANG Zun-jian LI Jing LI Wen-jing CHEN Yun Key Laboratory of Drug Quality Control Pharmacovigilance Center for Instrumental Analysis China Pharmaceutical University Nanjing |
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| Institution: | TIAN Yuan1,ZHANG Zun-jian1,LI Jing1,LI Wen-jing1,CHEN Yun2 1Key Laboratory of Drug Quality Control , Pharmacovigilance(Ministry of Education),Center for Instrumental Analysis,China Pharmaceutical University,Nanjing 210009,2Institute of Dermatology,Chinese Academy of Medical Sciences,Nanjing 210042,China |
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| Abstract: | Aim:To establish an analytical method for the simultaneous determination of norfloxacin,ofloxacin,pefloxacin,ciprofloxacin,lomefloxacin,danofloxacin,enrofloxacin,sarafloxacin and difloxacin in eggs using solid-phase extraction-LC-MS/MS.Methods:Egg samples were deproteinized with acetonitrile,followed by defatting with hexane.Then the samples were processed by solid-phase extraction and analyzed by LC-MS/MS using an electrospray source.The separation was carried out on a Shimadzu Shim-pack VP-ODS C18 column,... |
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| Keywords: | fluoroquinolones egg multiresidue LC-MS/MS solid-phase extraction |
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