| VEGFR-3在食管鳞癌中的表达及意义 |
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| 引用本文： | 马惠文,梁后杰. VEGFR-3在食管鳞癌中的表达及意义[J]. 第三军医大学学报, 2004, 26(24): 2197-2199 |
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| 作者姓名： | 马惠文 梁后杰 |
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| 作者单位： | 第三军医大学西南医院肿瘤科,重庆,400038;第三军医大学西南医院肿瘤科,重庆,400038 |
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| 摘 要： | 目的研究VEGFR-3在食管鳞癌中的表达特点及预后. 方法用免疫组织化学染色方法技术检测156例食管鳞癌组织中VEGFR-3的蛋白表达,结合临床资料分析随访3年的47例病例.结果有淋巴结转移的病例中VEGFR-3的表达明显高于无淋巴结转移组,VEGFR-3的表达与临床病理分期有相关性.47例随访3年的病例分析也表明VEGFR-3的表达与淋巴结转移有明显相关性(P<0.05).结论 VEGFR-3的表达与食管鳞癌的临床病理特点及预后有相关性.
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| 关 键 词： | 食管鳞癌 免疫组化 VEGFR-3 预后 |
| 文章编号： | 1000-5404(2004)24-2197-03 |
| 修稿时间： | 2004-03-19 |
VEGFR-3 expression in esophageal carcinoma and its significance |
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| MA Hui-wen,LIANG Hou-jie. VEGFR-3 expression in esophageal carcinoma and its significance[J]. Acta Academiae Medicinae Militaris Tertiae, 2004, 26(24): 2197-2199 |
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| Authors: | MA Hui-wen LIANG Hou-jie |
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| Abstract: | Objective To investigate of the expression of vascular endothelial growth factor receptor 3 (VEGFR-3) and its relationship with the prognosis of esophageal carcinoma. Methods VEGFR-3 in 156 cases of esophageal carcinoma tissues was detected by immunohistochemistry. The follow-up data for 3 years in 47 cases were analyzed. Results The VEGFR-3 expression in esophageal carcinoma tissues with lymph node metastasis was higher than that in those without lymph node metastasis. VEGFR-3 expression was associated with the clinicopathological stages. Analysis of the follow-up data also showed that there was a statistically positive correlation between VEGFR-3 expression and lymph node metastasis in primary tumors (P<0.05). Conclusion VEGFR-3 expression is closely associated with the clinicopathological characteristics and prognosis of esophageal carcinoma. |
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| Keywords: | VEGFR-3 |
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