可疑AD患者和抑郁性假性痴呆患者大脑血流速度的比较

目的 比较可疑阿尔茨海默病(AD)患者与抑郁性假性痴呆患者大脑血流速度的差异.方法 选择在我院就诊的可疑AD患者和抑郁性假性痴呆患者各20例；另外选取正常的志愿者20例.给予视觉刺激后,采用经颅多普勒检测受试者大脑后动脉血流速度,比较各组大脑血流速度的差异.结果 AD组和假性痴呆组患者左右侧大脑后动脉平均血流速度、静息血流速度、刺激血流速度和相对血流速度均低于对照组(P＜0.05),而AD组患者刺激时血流速度和相对血流速度明显低于假性痴呆组患者(P＜0.05).结论 可疑AD患者的神经血管耦联作用严重受损,可用于鉴别AD患者与假性痴呆患者.

Comparison of cerebral blood flow rate between patients suspected of alzheimer dementia and ones with depression pseudo-dementia

Objective To make comparison of differences in the cerebral blood flow rates between patients with suspected alzeheimer disease(AD) and the ones with depression pseudo-dementia.Methods Twenty patients with suspected AD and other 20 ones with depression pseudo-dementia in our hospital were selected.And 20 healthy volunteers were chosen as the controls.After receiving visual stimulation,their cerebral blood flow rates were detected by transcranial Doppler examination,and the differences were compared.Results The average blood flow rates of left and right side posterior cerebral artery,resting blood flow rates,blood flow rates at stimulation,and relative blood flow rates in the AD group and the pseudo-dementia group were all lower than those in the control group(P<0.05).The blood flow rates at stimulation and relative blood flow rates of patients with AD were significantly lower than those of the patients with depression pseudo-dementia(P<0.05).Conclusion Among the patients with suspected AD,the neurovascular coupled action is severely damaged,which can be used as the reference to distinguish AD from depression pseudo-dementia.