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| 基质金属蛋白酶与动脉粥样硬化斑块破裂研究进展 | |
| 引用本文： | 周新福,朱文玲. 基质金属蛋白酶与动脉粥样硬化斑块破裂研究进展[J]. 医学综述, 2008, 14(9): 1305-1307 |
| 作者姓名： | 周新福 朱文玲 |
| 作者单位： | 1. 山东威海市立医院心内科,山东,威海,264200 2. 北京协和医院心内科,北京,100730 |
| 摘 要： | 基质金属蛋白酶(MMPs)是降解细胞外基质最重要的酶类。动脉粥样硬化(AS)的形成是细胞外基质重构的过程,MMPs贯穿于AS发生、发展的全过程。近年来,人们对MMPs与急性冠状动脉综合征(ACS)的发生、发展进行了广泛深入的研究,大量证据表明,MMPs与AS斑块破裂、ACS的发生密切相关,起到了关键性作用。本文综述了MMPs与AS斑块破裂的研究进展。 |
| 关 键 词： | 基质金属蛋白酶 动脉粥样硬化 斑块破裂 |
| 文章编号： | 1006-2084(2008)09-1305-03 |
| 修稿时间： | 2005-11-01 |
Advancement in Relationship between Matrix Metalloproteinases and Atherosclerotic Plaque Rupture |
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| ZHOU Xin-fu,ZHU Wen-ling. Advancement in Relationship between Matrix Metalloproteinases and Atherosclerotic Plaque Rupture[J]. Medical Recapitulate, 2008, 14(9): 1305-1307 | |
| Authors: | ZHOU Xin-fu ZHU Wen-ling |
| Affiliation: | ZHOU Xin-fu1,ZHU Wen-ling2.(1.Dapartment of Cardiology,Weihai Municipal,Weihai 264200,China,2.Dapartment of Cardiology,Peking Union Medical College Hospital,Beijing 100730,China) |
| Abstract: | Matrix Metalloproteinases(MMPs)are the most important proteinase to degrade components of the extracellular matrix.MMPs has been demonstrated to be involved in the occurrence and development of atherosclerosis,the form of which is a process of the extracellular matrix remodeling.Many investigations have been made about the relationship of MMPs and ACS recently.The results showed MMPs play a key role in atherosclerotic plaque rupture resulting in ACS.This article reviewed the advancement in relationship betw... |
| Keywords: | Matrix metalloproteinases Atherosclerosis Plaque rupture |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |