可溶性细胞间粘附分子-1在妊娠期高血压疾病中的作用

目的:探讨可溶性细胞间粘附分子-1在妊娠期高血压疾病患者血浆中的变化,为临床诊治提供依据。方法:用ELISA法检测29例妊娠期高血压疾病患者血浆中可溶性细胞间粘附分子-1水平,并与正常妊娠组和正常对照组进行组间比较。结果:子痫前期组、妊娠期高血压组、正常妊娠组晚期及正常对照组的可溶性细胞间粘附分子-1水平分别为1129.82±399.16、794.35±255.57、661.51±301.79及549.23±139.98ng/ml。组间比较,子痫前期组与妊娠期高血压组之间P<0.05,与正常妊娠组晚期及正常对照组之间P<0.001;妊娠期高血压组与正常对照组之间P<0.001;妊娠期高血压组与正常妊娠组晚期相比P>0.05,正常妊娠组3个不同孕龄阶段P>0.05。结论:可溶性细胞间粘附分子-1在妊娠期高血压疾病时显著升高,并随病情的加重而增高,可作为该病诊断和监控的一项指标。

The roles of sICAM-1 on the pregnancy induced hypertension

Objective:To research plasma soluble intercellular adhesion molecule-1 (sICAM-1) in patient with pregnancy induced hypertension (PIH), make a diagnosis and give treatment to provide the basis for the clinic.Methods:Maternal plasma levels of sICAM-1 were measured with the ELISA in 29 patients with PIH to compare with that in normal gestation group and normal matched control.Results:The sICAM-1 levels in women with preeclampsia, the high blood pressure, the later period of the normal gestation and the normal matched control group were (1 129.82±399.16), (794.35±255.57), (661.51±301.79) and (549.23±139.98) ng/ml respectively. There were significant differences between preeclampsia group and high blood pressure group (P<0.05), between preeclampsia group and later period of the normal gestation group or normal matched control group (P<0.001), between high blood pressure group and normal matched control group (P<0.001). There were not significant differences between high blood pressure group and later period of normal gestation group (P>0.05). Similarly, the sICAM-1 level only varied slightly among the three different period of normal pregnancy (P>0.05).Conclusion:The expression of sICAM-1 in women with PIH is significantly higher, and increases gradually with the aggravation of PIH. The sICAM-1 can be served as an index of diagnosis and control of this disease.