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Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells |
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| Authors: | Mina Yaar Mark S Eller Izabela Panova John Kubera Lee Hng Wee Kenneth H Cowan Barbara A Gilchrest |
| Affiliation: | (1) Department of Dermatology, Boston University School of Medicine, Albany Street, 02118-2394 Boston, MA, USA;(2) Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Albany Street, 02118-2394 Boston, MA, USA;(3) Cancer Center, Boston University School of Medicine, Albany Street, 02118-2394 Boston, MA, USA;(4) Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 68198-6805 Omaha, NE, USA |
| Abstract: | IntroductionCancer is a leading cause of death in Americans. We have identified an inducible cancer avoidance mechanism in cells that reduces mutation rate, reduces and delays carcinogenesis after carcinogen exposure, and induces apoptosis and/or senescence of already transformed cells by simultaneously activating multiple overlapping and redundant DNA damage response pathways. |
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