儿童急性白血病血清乳酸脱氢酶测定的临床意义

目的 探讨乳酸脱氢酶在儿童急性白血病的诊治及预后判断中的临床价值.方法 以酶速率法检测42例初治急性白血病患儿化疗前、缓解后、复发后,同期病毒性心肌炎患儿50例(病毒性心肌炎组),同期健康体检儿童50例(正常对照组)比较血清乳酸脱氢酶水平的变化,测定初诊时骨髓原始 幼稚细胞比例和外周血白细胞计数.结果 儿童急性白血病初治时血清乳酸脱氢酶水平显著高于心肌炎患儿(P＜0.001)及健康对照组(P＜0.001),且与骨髓原始 幼稚细胞比例和外周血白细胞总数呈正相关(P＜0.05);完全缓解后乳酸脱氢酶水平显著低于初治时水平(P＜0.05),复发后乳酸脱氢酶水平显著高于缓解时水平(P＜0.05).结论 血清乳酸脱氢酶可鉴别儿童急性白血病良恶性、病情监测、疗效和预后判断.

Clinical value of serum LDH measurement in acute leukemia of children

Objective To detect the changes of serum LDH,and discuss its clinical significance in acute leukemia in children.Methods The levels of serum LDH in 42 cases of acute leukemia of children were assessed.The serum LDH levels before treatment,after remission or relapse were measured.Meanwhile,serum LDH was also detected in 50 cases of viral myocarditis and 50 healthy children respectively(normal control).Results Serum LDH in patients with acute leukemia at initial treatment was significantly higher than that of viral myocarditis(P< 0.001) and control subjects(P< 0.001),and positively correlated with the number of peripheral blood leucocyte,archaeocyte,and juvenile cells in bone marrow.The level of LDH after complete remission was lower than that of initial treatment(P< 0.05).The level of serum LDH after relapse was higher than that of complete remission(P< 0.05).Conclusion Serum LDH can be used as a reference marker in diagnosis,monitoring patients' condition,efficacy and prognosis evaluation in acute leukemia of children.