早期他汀类药物治疗对急性心肌梗死患者的益处

目的:探讨早期他汀类药物治疗对急性心肌梗死患者带来的益处。方法:571例急性心肌梗死患者分为他汀类药物治疗组和非他汀类药物治疗组,观察两组患者CK和CK-MB的峰值变化、发生充血性心力衰竭的风险和院内死亡率的变化情况。结果:他汀类药物治疗组院内死亡率、CK和CK-MB的峰值降低,进展为CHF的风险降低。结论:对急性心肌梗死患者在一般治疗的基础上早期应用他汀类药物治疗可获得很大的益处,且安全、可靠。

Benefits of Very Early Administration of Statins during the First Day of Hospitalization in Patients with Acute Myocardial Infarction

Objective To investigate the benefits of very early statin therapy in patients with acute myocardial infarction.Methods We identified 571 consecutive patients with AMI from 1998 to 2006 divided them into early statin therapy(statins were administered within the initial 24 h of hospitalization,n=165)and non-statin therapy groups(n=406).We compared mortality risks,rates of CHF development and measures of peak CK and CK-MB values between the groups.Results In-hospital mortality was lower in the early statin therapy group(2.9%)compared to the non-statin therapy group(10.3%),P<0.01.Patients with very early statin treatment had lower peak CK(605ng/ml)and CK-MB(41 ng/ml)values compared to non-statin patients(875 ng/ml and 92 ng/ml),P<0.01.Patients in the early statin group had lower risks of developing CHF during hospitalization(9.7%)compared to the non-statin group(27.2%),P<0.01.Conclousion Based on the traditional therapy,AMI can obtain many benefits from very early administration of statin therapy during the first day of hospitalization.It is an effective and safe method.