| 乙型肝炎患者HBV前C区变异及临床意义 |
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| 引用本文： | 胡耀仁,唐锡尔,应豪,周元龙,翁伦华,徐陈槐.乙型肝炎患者HBV前C区变异及临床意义[J].现代实用医学,1999(3). |
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| 作者姓名： | 胡耀仁 唐锡尔 应豪 周元龙 翁伦华 徐陈槐 |
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| 作者单位： | 宁波市传染病医院，浙江大学传染病研究所 |
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| 摘 要： | 目的研究乙型肝炎病毒（ＨＢＶ）前Ｃ区变异的临床意义。方法应用错配ＰＣＲ限制片段长度多态性分析，检测ＨＢＶ前Ｃ区１８９６位突变。结果６２０例乙型肝炎患者ＨＢＶ前Ｃ区１８９６位变异２６４例，变异率４２．５８％。在急性肝炎、慢性轻度、慢性中度、慢性重度、重型肝炎、肝硬化中，变异率分别为１２．５％、３５．０％、５５．９４％、４５．２６％、５４．７２％、４８．７６％。年龄、性别与变异无关，病程＞５年、谷丙转氨酶（ＡＬＴ）异常、抗ＨＢｅ（＋）者变异率均明显增高。结论ＨＢＶ前Ｃ区变异与肝病严重性有一定关系。
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| 关 键 词： | 聚合酶链反应 乙型肝炎病毒 前C区 突变 |
HBV pre-C mutation in patients with hepatitis B |
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| Hu Yaoren,Tang Xier,Ying Hao,et al..HBV pre-C mutation in patients with hepatitis B[J].Modern Practical Medicine,1999(3). |
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| Authors: | Hu Yaoren Tang Xier Ying Hao |
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| Institution: | Hu Yaoren,Tang Xier,Ying Hao,et al.
Ningbo Infectious Diseases Hospital,Ningbo 315010. |
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| Abstract: | Objective To investigate
HBV pre-C mutation rate and it's clinical significance . Methods HBV pre-C at 1896 mutation was
detected by mis-pair PCR restriction fragment length polymorphism(RFLP). Results 264 out of
620 patients with HBV infection had HBV pre-C mutation ,the total mutation rate was 42.58%.
Among acute hapatitis B,mildmiddle severe chronic hepatitis B and cirosis, the mutation rates
were 12.505.00% 55.94E.26T.72% and 48.76% respectively. It was obviously higher in
patients with disease durability over five years,or abnormal ALT and anti-HBe positive.
Conclusion HBV pre-C at 1896 mutation was relative with severity of liver diseases. |
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| Keywords: | olymerase chain reactionHepatitis B virusPre-CMutation |
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