Immunohistological analysis of macrophages in the central nervous system of Lewis rats with acute experimental allergic encephalomyelitis |
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| Authors: | C.H. Polman C.D. Dijkstra T. Sminia J.C. Koetsier |
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| Affiliation: | 1. Department of Neurology, Free University Hospital Free University, Amsterdam The Netherlands;2. Department of Histology, Medical Faculty, Free University, Amsterdam The Netherlands;1. Department of Orthopaedic Surgery, Washington University School of Medicine, Saint Louis, MO;2. Boston Children’s Hospital Orthopedic Center, Department of Orthopaedic Surgery, Children''s Hospital Boston, Boston, MA;3. TRIA Orthopedic Center, Department of Orthopedic Surgery, University of Minnesota, Bloomington, MN;4. Orthopedic Center, Nationwide Children’s Hospital, Columbus, OH;1. Department of Physiology, Faculty of Pharmacy, University of Belgrade, 450 Vojvode Stepe, 11221 Belgrade, Serbia;2. Immunology Research Centre “Branislav Janković”, Institute of Virology, Vaccines and Sera “Torlak”, 458 Vojvode Stepe, 11221 Belgrade, Serbia;3. Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, 450 Vojvode Stepe, 11221 Belgrade, Serbia;1. Shriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA;2. Department of Anatomy and Cell Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA;3. Department of Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA;4. Goodman Cancer Centre and Department of Biochemistry, McGill University, 1160 Pine Ave., Montreal, Quebec, Canada;1. Cellular and Molecular Research Centre, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran;2. Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran;3. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran;4. Medicinal Plants Research Centre, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran;1. Roth|McFarlane Hand and Upper Limb Center, St Joseph’s Health Care, University of Western Ontario, London, Ontario, Canada;2. Binghamton University, State University of New York, Binghamton, NY;3. University of Waterloo, Waterloo, Ontario, Canada |
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| Abstract: | ![]()
Inflammatory cells were characterized by immunohistochemistry, utilizing monoclonal antibodies specific for T cell subsets, B cells, Ia-positive cells and cells of the mononuclear phagocyte system, in cryostat sections of central nervous system of Lewis rats, sacrificed during the course of actively induced experimental allergic encephalomyelitis. The present study provides interesting information about the presence and distribution of cells of the monocyte-macrophage lineage in this immunologically mediated disease. Using these monoclonal antibodies different subpopulations of macrophages having varying distribution patterns in the central nervous system can be recognized. |
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| Keywords: | Central nervous system Experimental allergic encephalomyelitis Macrophages Monoclonal antibodies Rat |
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