EGFR、Her-2和细胞周期素A在食管鳞癌中的表达

目的：探讨食管鳞癌中EGFR信号传导通路相关分子（EGFR、Her-2）及细胞周期素A的表达情况及三者之间的相互关系。方法：随机选取食管鳞癌根治术后的切除标本76例和21例癌旁正常鳞状上皮组织,应用免疫组化法检测EGFR、Her-2和细胞周期素A的表达。结果：EGFR、细胞周期素A在食管鳞癌的表达明显高于癌旁正常鳞状上皮（63.2%vs 33.3%、61.8%vs 23.8%,P〈0.05）,Her-2在食管鳞癌低表达（3.9%）,正常鳞状上皮不表达;EGFR、Her-2和细胞周期素A均与脉管累犯、淋巴结转移正相关,此外,Her-2和细胞周期素A还与肿瘤浸润深度正相关;EGFR与细胞周期素A的表达成正相关（P〈0.01）,而Her-2与EGFR及细胞周期素A表达未发现相关关系。结论：EGFR和细胞周期素A在食管鳞癌中高表达可能与食管鳞癌的发生发展有关,并有可能成为靶向治疗的靶点,而Her-2在食管鳞癌由于表达很低,有可能不是该肿瘤分子治疗的靶点。

Expressions of EGFR,Her - 2 and CyclinA in esophageal squamous cell carcinoma

Objective： To explore the expressions of EGFR,Her-2 and CyclinA in esophageal squamous cell carcinoma（ESCC） and their relationship with clinicopathological parameters.Methods： The expressions of EGFR,Her-2 and CyclinA were examined by immunohistochemistry（IHC） in 76 surgically obtained ESCC specimens（group ESCC） and in 21 specimens of tumor-adjacent normal squamous epithelium as the controls（group C）.Results：The expressions of EGFR（63.2%）,CyclinA（61.8%） were higher in group ESCC than those in group C（33.3% 、 23.8%,P 0.05）.In group ESCC,Her-2 expression was low in group ESCC and no expression in group C.EGFR,Her-2 and CyclinA were correlated to vascular recidivism,lymph node metastasis.Besids,Her-2 and CyclinA were correlated to invasion of ESCC cells.Expression of EGFR and CyclinA was positive related;No relationship was found between Her-2 and EGFR,CyclinA.Conclusion： The high expressions of EGFR and CyclinA may correlate to tumor genesis and development of esophageal carcinoma and may be a new target for targeted therapy of esophageal carcinoma;The expressions of Her-2 was low,and may be not the target of esophageal carcinoma.