| 直肠癌术后放化疗联合DC-CIK回顾性疗效分析 |
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| 引用本文： | 魏植强,杨建伟,陈路川,郑秋红,应敏刚.直肠癌术后放化疗联合DC-CIK回顾性疗效分析[J].福建医科大学学报,2009,43(6):483-487. |
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| 作者姓名： | 魏植强 杨建伟 陈路川 郑秋红 应敏刚 |
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| 作者单位： | 福建医科大学教学医院,福建省肿瘤医院,福州350014 |
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| 基金项目： | 福建省自然科学基金 |
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| 摘 要： | 目的探讨放化疗联合树突细胞-细胞因子诱导的杀伤细胞（DC-CIK）疗法的临床疗效。方法回顾性分析41例直肠癌根治术后行放化疗联合DC-CIK细胞疗法患者的临床资料,以性别、年龄、肿瘤分化程度、AJCC（1997）中的TNM临床分期、手术方式、术后辅助化疗的方案、是否实施全直肠系膜切除术、是否接受术后辅助放疗为指标,采用1∶2配对方法在同期接受直肠癌根治术但未接受DC-CIK细胞疗法的患者中选择82例作为对照,采用Kaplan-Meier法计算生存率,采用单因素和多因素Cox回归法分析直肠癌的预后影响因素,对比两组的3年生存率（OS）和3年无病生存率（DFS）。结果单因素分析表明,肿瘤分化程度、TNM分期、是否实施全直肠系膜切除术、是否实施DC-CIK治疗为直肠癌预后的影响因素。术后辅助放疗是Ⅱ、Ⅲ期直肠癌的预后影响因素。多因素回归分析表明,TNM分期、是否实施全直肠系膜切除术、是否接受术后辅助放疗、是否实施DC-CIK治疗是Ⅱ、Ⅲ期直肠癌的独立预后因素。DC-CIK治疗组3年生存率（OS）（73.2%vs56.1%）,差别具有统计学意义（P〈0.05）。DC-CIK治疗组3年无病生存率（DFS）（58.5%vs41.5%）,差别具有统计学意义（P〈0.05）。结论TNM分期、是否实施全直肠系膜切除术、是否接受术后辅助放疗、是否实施DC-CIK治疗是Ⅱ、Ⅲ期直肠癌的独立预后因素。直肠癌根治术后放化疗联合DC-CIK细胞疗法有可能改善患者的远期生存率和无病生存率。
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| 关 键 词： | 直肠肿瘤 化学疗法 辅助 树突细胞 细胞因子类 存活率 |
A Retrospective Analysis of Postsurgical Treatment for Rectal Cancer by Chemotherapy and Radiotherapy Combined with Dendritic Cells and Cytokine-Induced Killer Cells |
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| WEI Zhiqiang,YANG Jianwei,CHEN Luchuan,ZHENG Qiuhong,YING Mingang.A Retrospective Analysis of Postsurgical Treatment for Rectal Cancer by Chemotherapy and Radiotherapy Combined with Dendritic Cells and Cytokine-Induced Killer Cells[J].Journal of Fujian Medical University,2009,43(6):483-487. |
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| Authors: | WEI Zhiqiang YANG Jianwei CHEN Luchuan ZHENG Qiuhong YING Mingang |
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| Institution: | WEI Zhiqiang,YANG Jianwei,CHEN Luchuan,ZHENG Qiuhong,YING MingangFujian Provincial Tumor Hospital,The Affiliated Teaching Hospital of Fujian Medical University,Fuzhou 350014,China |
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| Abstract: | Objective To evaluate the effect of chemotherapy and radiotherapy combined with dendritic cells and cytokine-induced killer cells(DC-CIK) on rectal cancer after radical resection.Methods A retrospective review was conducted to study the clinical data of 41 patients treated by adjuvant chemotherapy and radiotherapy combined with DC-CIK after radical resection.These patients were compared with a cohort of 82 rectal cancer patients treated by adjuvant chemotherapy and radiotherapy only after radical resection ... |
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| Keywords: | rectal neoplasms chemotherapy adjuvant dendritic cells cytokines survival rate |
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