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Successful Lung Transplantation From Hepatitis C Positive Donor to Seronegative Recipient |
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| Authors: | B. Khan L. G. Singer L. B. Lilly C. Chaparro T. Martinu S. Juvet M. Pipkin T. K. Waddell S. Keshavjee A. Humar M. Cypel |
| Affiliation: | 1. Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Canada;2. Toronto Multi‐Organ Transplant Program, University of Toronto, Toronto, Canada |
| Abstract: | Lung transplantation using RNA+ hepatitis C (HCV+) donors to seronegative recipients is not currently performed due to the very high risk of transmission. Previous reports have shown poor survival when this practice was applied. The emergence of new direct‐acting antiviral drugs (DAA) suggests a high chance of sustained virologic response in immunocompetent patients. We report here successful transplantation of lungs from HCV+ donor to HCV? recipient. The recipient was an HCV? patient with chronic lung allograft dysfunction. Viral transmission occurred early posttransplant but excellent clinical outcomes were observed including elimination of HCV after 12 weeks of treatment using DAAs. |
| Keywords: | clinical research/practice translational research/science infectious disease lung transplantation/pulmonology organ procurement and allocation complication: infectious donors and donation: donor‐derived infections donors and donation: extended criteria lung disease |