铁代谢与新生儿缺氧缺血性脑病

铁稳态的维持对机体至关重要,铁承担着氧运输和电子传递,并参与神经递质和髓鞘的合成.近年来大量的研究发现铁在局部沉积将对机体产生毒害作用,特别是铁过剩现象出现在中枢神经系统的组织和细胞,甚至是神经细胞的细胞器内,将导致中枢神经系统发生不可逆转的病理性改变.该文综述了脑缺氧缺血后脑中铁及循环铁的变化,并讨论了铁代谢与新生儿缺氧缺血性脑病发病机制方面的研究进展.

Iron metabolism and neonatal hypoxic-ischemic encephalopathy

Iron homeostasis is essential for the maintenance of the body. Iron transports oxygen and electron, and participates in the synthesis of neurotransmitters and myelin. However, iron overload in the body is harmful. In recent years studies have found iron deposition would be poisoned significantly, particularly in the central nervous system tissues and nerve cells, which will cause pathological changes of central nervous system.This paper describes the iron and cycled iron changes in hypoxic-ischemic brain, abnormal iron metabolism and mechanisms of HIE.