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| 造血干细胞移植后出血性膀胱炎 | |
| 引用本文： | 林文远,赖永榕,程鹏,马劼,罗琳,龙媛,刘容容. 造血干细胞移植后出血性膀胱炎[J]. 血栓与止血学, 2007, 13(5): 226-228 |
| 作者姓名： | 林文远 赖永榕 程鹏 马劼 罗琳 龙媛 刘容容 |
| 作者单位： | 1. 桂林医学院附属医院,桂林,541001 2. 广西医科大学第一附属医院,南宁,530021 |
| 摘 要： | 目的探讨造血干细胞移植（HSCT）后出血性膀胱炎（HC）的发病相关因素及治疗措施。方法观察135例HSCT患者HC的发生情况，就其发生因素进行分析，并对HC的预防和治疗进行临床评价。结果HC发病率为10．4％，中位发病时间36．5d（11-54d），平均病程20．1d（7-50d），经过积极治疗均可好转或治愈；无关供者与HC发病明显相关。结论异基因造血干细胞移植尤其是无关供者的移植是引起HC的危险因素。 |
| 关 键 词： | 出血性膀胱炎 造血干细胞移植 无关供者 |
| 文章编号： | 1009-6213（2007）05-226-03 |
| 修稿时间： | 2007-05-10 |
Post-Hematopoietic Stem Cell Transplantation Hemorrhagic Cystitis |
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| LIN Wen-yuan,LAI Yong-rong,CHENG Peng,MA Jie,LUO Ling,LONG Yuan,LIU Rong-rong. Post-Hematopoietic Stem Cell Transplantation Hemorrhagic Cystitis[J]. Chinese Journal of Thrombosis and Hemostasis, 2007, 13(5): 226-228 | |
| Authors: | LIN Wen-yuan LAI Yong-rong CHENG Peng MA Jie LUO Ling LONG Yuan LIU Rong-rong |
| Affiliation: | 1. The Affiliated Hospital,Guilin Medical College, Guilin 541001, China;2. The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China |
| Abstract: | Objective To analyze the risk factors and treatment of hemorrhagic cystitis (HC)in recipients who underwent hematopoietic stem cell transplantation.Methods We analyzed the incidence and risk factors for hemorrhagic cystitis in 135 patients undergoing hematopoietic stem cell transplantation (HSCT). The curative effect was observed.Results 14 out of 135(10.4%) patients developed HC. The average time of onset and the average duration was 36.5 days and 20.1 days respectively. After treatment, all of them had complete remission; unrelated donor (OR=7.594, 95%CI 2.425~23.779; P=0.000) were identified as being significantly associated with the occurrence of HC.Conclusion Multiple regression analysis revealed unrelated donor graft recipients to be significant factors. |
| Keywords: | Hemorrhagic cystitis Hematopoietic stem cell transplantation Unrelated donor |
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